328548-23-8Relevant academic research and scientific papers
B-ring substituted 5,7-dihydroxyflavonols with high-affinity binding to P-glycoprotein responsible for cell multidrug resistance
Boumendjel, Ahcene,Bois, Frederic,Beney, Chantal,Mariotte, Anne-Marie,Conseil, Gwenaelle,Di Pietro, Attilio
, p. 75 - 77 (2001)
Starting from the interaction of galangin (3,5,7-trihydroxyflavone) with a cytosolic nucleotide-binding domain of P-glycoprotein, a series of flavonol derivatives was synthesized and tested for their binding affinity towards the same target. The 5,7-dihyd
