328565-20-4Relevant academic research and scientific papers
COMPOUNDS FOR USE IN THE TREATMENT OF ACUTE INTERMITTENT PORPHYRIA
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Page/Page column 38, (2021/05/29)
The invention provides compounds of formula (I), their pharmaceutically acceptable salts and prodrugs thereof for use in preventing, inhibiting or treating a disease caused by a mutation in the gene coding for hydroxymethylbilane synthase, in particular f
Structure-activity relationship study on col-003, a protein-protein interaction inhibitor between collagen and Hsp47
Yoshida, Masahito,Saito, Masazumi,Ito, Shinya,Ogawa, Koji,Goshima, Naoki,Nagata, Kazuhiro,Doi, Takayuki
, p. 220 - 226 (2020/11/26)
This study demonstrates the structure-activity relationship of Col-003, a potent collagen-heat-shock protein 47 (Hsp47) interaction inhibitor. Col-003 analogues were successfully synthesized by Pd(0)-catalyzed cross-coupling reactions of 5-bromosalicylald
Palladium- and nickel-catalyzed cross-couplings of unsaturated halides bearing relatively acidic protons with organozinc reagents
Manolikakes, Georg,Munoz Hernandez, Carmen,Schade, Matthias A.,Metzger, Albrecht,Knochel, Paul
supporting information; experimental part, p. 8422 - 8436 (2009/04/11)
(Chemical Equation Presented) A wide range of polyfunctional aryl, heteroaryl, alkyl, and benzylic zinc reagents were coupled with unsaturated aryl halides bearing an acidic NH or OH proton, using Pd(OAc)2 (1 mol %) and S-Phos (2 mol %) as catalyst without the need of protecting groups. A similar nickel-catalyzed reaction is described. The relative kinetic basicity of organozinc compounds as well as their stability toward acidic protons is also described.
Negishi cross-couplings of unsaturated halides bearing relatively acidic hydrogen atoms with organozinc reagents
Manolikakes, Georg,Schade, Matthias A.,Hernandez, Carmen Munoz,Mayr, Herbert,Knochel, Paul
supporting information; experimental part, p. 2765 - 2768 (2009/05/27)
(Chemical Equation Presented) A wide range of polyfunctional aryl, heteroaryl, alkyl, and benzylic zinc reagents were coupled with unsaturated halides bearing an acidic NH or OH function, using Pd(OAc)2 (1 mol %) and S-Phos (2 mol %) as catalyst without the need of protecting groups.
