3286-91-7Relevant academic research and scientific papers
Method for separating and purifying 5-chloro-2-hydroxy-4-methoxybenzophenone
-
Paragraph 0014, (2019/01/14)
The invention discloses a method for separating and purifying 5-chloro-2-hydroxy-4-methoxybenzophenone. The method includes the following steps: 1) recovering a solvent in the refining process of 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid to obtain a distillation concentrate and adding a sulfuric acid solution for reduction reaction with the temperature controlled at 80-130 DEG C; 2) conducting layering after reaction in the step 1), taking an organic phase in the lower layer, mixing with a mixed solvent composed of halogenated hydrocarbon and ester, cooling for crystallization, and distilling the remaining liquid substance to remove the mixed solvent to obtain a crude product of the 5-chloro-2-hydroxy-4-methoxybenzophenone; 3) adding the crude product of the 5-chloro-2-hydroxy-4-methoxybenzophenone into an alcohol solvent for recrystallization to obtain a pure product of the 5-chloro-2-hydroxy-4-methoxybenzophenone. In the preparation process of the 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, active components of the refined mother liquor recovered concentrate is subjected to reduction, purification and purification, re-refining and purification to achieve separation andrecovery of target components.
Stability and toxicity of selected chlorinated benzophenone-type uv filters in waters
Zhuang, Rensheng,?abar, Romina,Grbovi??, Gorica,Dolenc, Darko,Yao, Jun,Ti?ler, Tatjana,Treb?e, Polonca
, p. 826 - 832 (2014/01/17)
In our study, the transformation of two most widely used UV filters, benzophenone-3 (BP3) and benzophenone-4 (BP4), in chlorinated water with disinfection reagents sodium hypochlorite (NaClO) and trichloroisocyanuric acid (TCCA) was studied. Based on the
Studies on uricosuric diuretics. II. Substituted 7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acids and 7,8-dihydrofuro[2,3-g]benzoxazole-7-carboxylic acids
Sato,Dan,Onuma,Tanaka,Aoki,Koga
, p. 1760 - 1772 (2007/10/02)
A series of substituted 7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acids and 7,8-dihydrofuro[2,3-g]benzoxazole-7-carboxylic acids were synthesized and evaluated for uricosuric and diuretic activities in rats. Many of the benzisoxazole derivatives showed uricosuric and only weak diuretic activities, whereas the benzoxazoles exhibited potent diuretic activities with little affecting urate excretion. Among these compounds, 5-chloro-7,8-dihydro-3-phenylfuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acid (AA-193) was found to be a potent uricosuric agent without diuretic activity and was selected for further development.
