3289-19-8

Usage

Uses

Used in Organic Synthesis:
TERT-BUTYL (3-BROMO-2-OXOPROPYL)CARBAMATE is used as a reagent for its ability to react with various nucleophiles, facilitating the formation of new carbon-carbon or carbon-nitrogen bonds. This makes it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
TERT-BUTYL (3-BROMO-2-OXOPROPYL)CARBAMATE is used as a building block for the synthesis of pharmaceuticals. Its versatile reactivity and the presence of functional groups that can be easily modified make it a promising candidate for the development of new drugs.
Used in Agrochemical Industry:
TERT-BUTYL (3-BROMO-2-OXOPROPYL)CARBAMATE is used as a precursor in the synthesis of agrochemicals. Its reactivity and functional groups contribute to the creation of compounds that can be used in the development of pesticides and other agricultural chemicals.

Upstream product

• 3416-57-7 N-acetonylphthalimide 
• 107-21-1 ethylene glycol 
• 1775-18-4 N-(2-methyl-[1,3]dioxolan-2-ylmethyl)-phthalimide 
• 1028068-08-7 benzyl (2-methyl-1,3-dioxolan-2-yl)methylcarbamate 

Downstream Products

• 862457-85-0 (2-methyl[1,3]dioxolan-2-ylmethyl)-(5-phenyl-7,9-dihydro-1,3-dioxa-6,7-diazacyclohepta[f]inden-8-ylidene)amine 
• 1071140-58-3 (R,S)-7,8-dimethoxy-3-[N'-(2,2-ethylenedioxy-1-propyl)-carbamoyl]-4-methyl-1-(4-nitrophenyl)-4,5-dihydro-[2,3]benzodiazepine 
• 871477-03-1 C₁₁H₁₁ClN₂S 
• 452974-03-7 (2-methyl-[1,3]dioxolan-2-ylmethyl)-[8-(4-nitro-phenyl)-[1,3]dioxolo[4,5-g]phthalazin-5-yl]-amine 
• 452974-05-9 [6-chloro-4-(4-nitro-phenyl)-phthalazin-1-yl]-(2-methyl-[1,3]dioxolan-2-ylmethyl)-amine 

Relevant academic research and scientific papers

Tuning gelation time and morphology of injectable hydrogels using Ketone-Hydrazide cross-linking

Injectable, covalently in situ forming hydrogels based on poly(N-isopropylacrylamide) have been designed on the basis of mixing hydrazide-functionalized nucleophilic precursor polymers with electrophilic precursor polymers functionalized with a combination of ketone (slow reacting) and aldehyde (fast reacting) functional groups. By tuning the ratio of aldehyde:ketone functional groups as well as the total number of ketone groups in the electrophilic precursor polymer, largely independent control over hydrogel properties including gelation time (from seconds to hours), degradation kinetics (from hours to months), optical transmission (from 1 to 85%), and mechanics (over nearly 1 order of magnitude) can be achieved. In addition, ketone-functionalized precursor polymers exhibit improved cytocompatibility at even extremely high concentrations relative to polymers functionalized with aldehyde groups, even at 4-fold higher functional group densities. Overall, increasing the ketone content of the precursor copolymers can result in in situ-gellable hydrogels with improved transparency and biocompatibility and equivalent mechanics and stimuli-responsiveness while only modestly sacrificing the speed of gel formation.

POLY(OLIGOETHYLENE GLYCOL METHACRYLATE) HYDROGEL COMPOSITIONS, AND METHODS OF USE THEREOF

The present application relates to hydrogel compositions comprising first and second precursor polymers, wherein the precursor polymers are modified poly(oligoethylene glycol methacrylate) copolymers that are crosslinked through electrophile-nucleophile reactions.

ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF

The present application is related to compounds represented by Formula I, which are novel positive allosteric modulators of α7 nAChRs. The application also discloses the treatment of disorders that are responsive to enhancement of acetylcholine action on α7 nAChRs in a mammal by administering an effective amount of a compound of Formula I.

γ-Carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity

Based on anti-viral screening of our heteroaromatics derived from thalidomide, the γ-carboline skeleton has been identified as a superior scaffold structure for compounds with potent anti-bovine viral diarrhea virus (BVDV) activity. Structural development studies led to a potent anti-viral agent, SK5M (5-methyl-γ-carboline), with the EC50 of 0.26 μM.

NOVEL SUBSTITUTED 2-AMINOIMIDAZOLES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS A MEDICAMENT OR AS A DIAGNOSTIC REAGENT, AND MEDICAMENT CONTAINING THESE COMPOUNDS

The invention relates to compounds of formula (I) whose radicals R1-R8 are defined as in the claims. Compounds of this type are useful in the prevention or treatment of diverse disorders. They can be used, among other things, in the treatment of: kidney d

Hetrazepine compounds which have useful pharmaceutical utility

The invention relates to new hetrazepines of general formula STR1 wherein A, Z, n, X, Y, R 1, R 2, R 3 and R 4 have the meanings given in the specification.The new compounds are intended for use in treating pathological conditions and diseases in which PAF (platelet activating factor) is implicated.