328945-99-9

Upstream product

• 494773-45-4 4-bromo-3-hydroxy-phenyl 4-methyl-benzenesulfonate 
• 98-59-9 p-toluenesulfonyl chloride 
• 108-46-3 recorcinol 
• 41046-68-8 4-iodobenzene-1,3-diol 
• 6626-15-9 4-Bromoresorcinol 
• 74-88-4 methyl iodide 
• 137396-01-1 4-bromo-3-methoxyphenyl 4-methylbenzenesulfonate 

Downstream Products

• 328945-93-3 toluene-4-sulfonic acid 3-methoxy-4-trimethylsilanylethynyl-phenyl ester 
• 941574-05-6 C₂₉H₂₄O₅S 
• 57800-41-6 Vignafuran 
• 479-13-0 coumestrol 
• 328945-90-0 2-Methoxy-4-(tosyloxy)phenylacetylene 
• 796089-78-6 coumestrol 
• 328945-96-6 6-Methoxy-2-[2-methoxy-4-(tosyloxy)phenyl]benzo[b]furan 
• 328945-95-5 2-Hydroxy-2',4-dimethoxy-4'-(tosyloxy)diphenylacetylene 
• 328945-88-6 2-Acetoxy-2',4-dimethoxy-4'-(tosyloxy)diphenylacetylene 
• 328945-97-7 Methyl 6-methoxy-2-[2-methoxy-4-(tosyloxy)phenyl]benzo[b]furan-3-carboxylate 
• 328945-98-8 Methyl 6-hydroxy-2-[2-hydroxy-4-(tosyloxy)phenyl]benzo[b]furan-3-carboxylate 
• 941573-96-2 C₂₈H₂₁IO₅S 

Relevant academic research and scientific papers

Total syntheses of three natural products, vignafuran, 2-(4-hydroxy-2-methoxyphenyl)-6-methoxybenzofuran-3-carboxylic acid methyl ester, and coumestrol from a common starting material

Vignafuran 2, 2-(4-hydroxy-2-methoxyphenyl)-6-methoxybenzofuran-3-carboxylic acid methyl ester 3, and coumestrol 4 were efficiently synthesized from the same starting material, 4-bromoresorcinol 14a, through the common intermediate, diarylacetylene 7. The key steps of these syntheses were the tetrabutylammonium fluoride (TBAF)-catalyzed benzo[b]furan ring formation for 2 and the carbonylative ring closure methodology catalyzed by a Pd complex for 3 and 4. The Royal Society of Chemistry 2000.