32896-91-6

Basic information

• Product Name: 3-nitro-1-methyl-2(1H)-pyridinone
• Synonyms: 3-nitro-1-methyl-2(1H)-pyridinone;1-Methyl-3-nitropyridin-2(1H)-one
• CAS NO: 32896-91-6
• Molecular Formula: C₆H₆N₂O₃
• Molecular Weight: 154.12344
• Mol File: 32896-91-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 176 °C
• Boiling Point: 314.1°Cat760mmHg
• Flash Point: 143.8°C
• Appearance: /
• Density: 1.37g/cm³
• Vapor Pressure: 0.000476mmHg at 25°C
• Refractive Index: 1.582
• Storage Temp.: 2-8°C
• PKA: -5.28±0.62(Predicted)
• CAS DataBase Reference: 3-nitro-1-methyl-2(1H)-pyridinone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-nitro-1-methyl-2(1H)-pyridinone(32896-91-6)
• EPA Substance Registry System: 3-nitro-1-methyl-2(1H)-pyridinone(32896-91-6)

Safety Data

• Hazardous Substances Data: 32896-91-6(Hazardous Substances Data)

Usage

General Description

3-nitro-1-methyl-2(1H)-pyridinone is a chemical compound with the molecular formula C6H6N2O3. It is also known as N-methyl-3-nitro-2-pyridone and is used in the production of various pharmaceuticals and agrochemicals. 3-nitro-1-methyl-2(1H)-pyridinone is a nitro derivative of pyridinone and is known for its strong bactericidal and fungicidal properties, making it a valuable ingredient in the production of pesticides and anti-infective medications. It is a pale yellow crystalline powder that is soluble in organic solvents and is stable under normal conditions. Additionally, it is an intermediate in the synthesis of other organic compounds and is used in the pharmaceutical industry for the production of antibiotics and other medicinal products.

InChI:InChI=1/C6H6N2O3/c1-7-4-2-3-5(6(7)9)8(10)11/h2-4H,1H3

Upstream product

• 6332-56-5 3-nitropyridone 
• 74-88-4 methyl iodide 
• 6332-56-5 2-hydroxy-3-nitropyridine 
• 77-78-1 dimethyl sulfate 

Relevant articles and documents

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Pyrrolopyrimidine derivative as well as preparation method and application thereof

The invention belongs to the technical field of medicines, and provides a compound shown as a general formula (I), geometric isomers or pharmaceutically acceptable salts, hydrates, solvates and prodrugs thereof, and preparation methods thereof, wherein A, B and R1 are described in the claims and the specification. The compound and the geometric isomer thereof or the pharmaceutically acceptable salt, hydrate, solvate, prodrug or pharmaceutical composition thereof have the activity as a protein kinase inhibitor, especially an FAK kinase inhibitor.

Design, synthesis and biological evaluation of novel 7H-pyrrolo[2,3-d]pyrimidine derivatives as potential FAK inhibitors and anticancer agents

A series of 7H-pyrrolo[2,3-d]pyrimidine derivatives possessing a dimethylphosphine oxide moiety were designed, synthesized and evaluated as novel Focal adhesion kinase (FAK) inhibitors. Most compounds potently suppressed the enzymatic activities of FAK, with IC50 values in the 10?8–10?9 M range, and potently inhibited the proliferation of breast (MDA-MB-231) and lung (A549) cancer cell lines. The representative compound 25b exhibited potent enzyme inhibition (IC50 = 5.4 nM) and good selectivity when tested on a panel of 26 kinases. 25b exhibited antiproliferative activity against A549 cells (IC50 = 3.2 μM) and relatively less cytotoxicity to a normal human cell line HK2. Compound 25b also induced apoptosis and suppressed the migration of A549 cells in a concentration-dependent manner. Further profiling of compound 25b revealed it had good metabolic stability in mouse, rat and human liver microsomes in vitro and showed weak inhibitory activity against various subtypes of human cytochrome P450. The docking study of compound 25b was performed to elucidate its possible binding modes and to provide a structural basis for further structure-guided design of FAK inhibitors.