329-30-6

Basic information

• Product Name: TPCK
• Synonyms: N-TOSYL-L-PHENYLALANINE CHLOROMETHYL KETONE;N-TOSYL-PHE-CHLOROMETHYLKETONE;N-TOSYLAMIDE PHENETHYL CHLOROMETHYLKETONE;N-ALPHA-TOSYL-PHE CHLOROMETHYL KETONE;N-ALPHA-P-TOSYL-L-PHENYLALANINE CHLOROMETHYIKETONE;(S)-1-CHLORO-3-TOSYLAMIDO-4-PHENYL-2-BUTANONE;(S)-1-CHLORO-4-PHENYL-3-TOSYLAMIDO-2-BUTANONE;P-TOLUENESULFONYL-L-PHENYLALANINE CHLOROMETHYL KETONE
• CAS NO: 329-30-6
• Molecular Formula: C17H18ClNO3S
• Molecular Weight: 351.85
• EINECS: 206-954-6
• Mol File: 329-30-6.mol
• Article Data: 0

Chemical Properties

• Melting Point: 106-108 °C(lit.)
• Boiling Point: 509.9°Cat760mmHg
• Flash Point: 262.2°C
• Appearance: white/powder
• Density: 1.277g/cm³
• Storage Temp.: −20°C
• Solubility: DMSO: >10 mg/mL stable for several months at 4°C.
• CAS DataBase Reference: TPCK(CAS DataBase Reference)
• NIST Chemistry Reference: TPCK(329-30-6)
• EPA Substance Registry System: TPCK(329-30-6)

Safety Data

• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: XT5613500
• F: 10-19-21
• Hazardous Substances Data: 329-30-6(Hazardous Substances Data)

Usage

General Description

TPCK, or N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a chemical compound commonly used as a serine protease inhibitor. It is a reversible inhibitor that selectively blocks the activity of the enzyme trypsin by irreversibly binding to the active site of the enzyme and preventing it from cleaving its substrate. TPCK is widely used in biochemical and pharmaceutical research to study the function and regulation of proteases, as well as in the purification and characterization of proteins. Additionally, TPCK has been implicated in the potential treatment of viral infections and neurological diseases by targeting specific proteases involved in these conditions.