329024-94-4Relevant academic research and scientific papers
2-(3-Methoxyphenyl)quinazoline Derivatives: A New Class of Direct Constitutive Androstane Receptor (CAR) Agonists
Smutny, Tomas,Nova, Alice,Drechslerová, Marcela,Carazo, Alejandro,Hyrsova, Lucie,Hru?ková, Zuzana Rania,Kune?, Ji?í,Pour, Milan,?pulák, Marcel,Pavek, Petr
, p. 4601 - 4610 (2016)
Constitutive androstane receptor (CAR) is a key regulator of xenobiotic and endobiotic metabolism. Together with pregnane X (PXR) and aryl hydrocarbon (AHR) receptors, it is referred to as xenobiotic receptor. The unique properties of human CAR, such as i
Efficient Synthesis of Quinazolines from Aryl Imidates and N-Alkoxyamide by Ir(III)-Catalyzed C?H Amidation/Cyclization
Fan, Wei-Tai,Huang, Zhibin,Xu, Xu,Tu, Guangliang,Geng, Jingyao,Ji, Shun-Jun,Zhao, Yingsheng
supporting information, p. 4144 - 4147 (2021/08/24)
An Ir(III) catalyst was used for the first time to realize the synthesis of quinazolines by C?H bond activation/cyclization with N-alkoxyamides as amidation reagents. This reaction has the advantages of wide substrate adaptability, good to excellent yield
A Comparative Investigation: Group 9 Cp?M(III)-Catalyzed Formal [4 + 2] Cycloaddition as an Atom-Economic Approach to Quinazolines
Wang, Xiaoming,Lerchen, Andreas,Glorius, Frank
supporting information, p. 2090 - 2093 (2016/06/01)
A comparative study on the catalytic activity of different group 9 [Cp?M(III)] complexes in the formal [4 + 2] cycloaddition of arenes with rarely explored free imines and dioxazolones for the construction of multisubstituted quinazolines is reported herein. This investigation revealed that the cobalt catalyst is uniquely suited to this transformation due to its strong Lewis acidity and high sensitivity to steric hindrance.
