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Upstream product

• 1899-24-7 5-bromo-2-furancarboxaldehyde 
• 201802-67-7 4-(diphenylamino)phenyl boronic acid 
• 27329-70-0 5-formylfurane-2-boronic acid 
• 36809-26-4 4-N,N-diphenylamino-1-bromobenzene 

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• 1096712-03-6 (E)-3-(5-(4-(diphenylamino)phenyl)furan-2-yl)-2-cyanoacrylic acid 

Relevant academic research and scientific papers

Tuning photophysical properties of triphenylamine and aromatic cyano conjugate-based wavelength-shifting compounds by manipulating intramolecular charge transfer strength

A series of triphenylamine-based aromatic cyano compounds have been synthesized as red-emitting fluorophores with large Stokes shifts in both solution (>100 nm in CHCl3) and solid state (>150 nm in film). Intramolecular charge transfer (ICT) properties of the synthesized compounds are examined using UV-Vis absorptions, photoluminescence measurements and solvatochromic studies. Our studies suggest that Stokes shifts of these compounds can be fine-tuned by manipulating the ICT strength between donor and acceptor with various electronic donating groups, and the largest Stokes shifts are typically associated with compounds that have the strong ICT characters. The observed spectroscopic properties of the compounds are consistent with theoretical calculations using density function theory (DFT) or time-dependent density function theory (TD-DFT). The calculations suggest that the ICT occurs from localized HOMO to localized LUMO with magnitudes of 60-80%. The relative quantum yields of these fluorophores in solution are various and highly solvent dependent. In solid state, the quantum yields of the compounds are significantly increased and some can reach to 0.40.

Exploring the Changes of Peroxisomal Polarity in the Liver of Mice with Nonalcoholic Fatty Liver Disease

Peroxisome proliferator-activated receptor alpha (PPAR-a) is a crucial nuclear transcription regulator of lipid metabolism, which is closely associated with the initiation and development of nonalcoholic fatty liver disease (NAFLD). Because PPAR-a can directly decide the level of peroxisomal metabolic enzymes, its changes might directly cause variations in peroxisomal polarity. Therefore, we developed a new two-photon fluorescence imaging probe, PX-P, in which the triphenylamine and cyanide moieties can real-time sense peroxisomal polarity changes. Using PX-P, we observed a prominent decrease in the peroxisomal polarity in the liver of mice with NAFLD for the first time. More importantly, we discovered that intracellular excessive peroxynitrite (ONOO-) and hydrogen peroxide (H2O2) underwent nitrification and oxidation, respectively, with various sites of PPAR-a. Interestingly, the key site of PPAR-a was nitrated by a low concentration of ONOO-rather than being oxidized by the high level of H2O2. These drastically reduced the activity of PPAR-a, accelerating the occurrence of NAFLD. Moreover, through activating PPARs with pioglitazone, peroxisomal polarity markedly increased compared with that of NAFLD. Altogether, our work presents a new approach for the early diagnosis of NAFLD and identifies potential therapeutic targets.

Three-Pronged Attack by Homologous Far-red/NIR AIEgens to Achieve 1+1+1>3 Synergistic Enhanced Photodynamic Therapy

Photodynamic therapy (PDT) has long been shown to be a powerful therapeutic modality for cancer. However, PDT is undiversified and has become stereotyped in recent years. Exploration of distinctive PDT methods is thus highly in demand but remains a severe challenge. Herein, an unprecedented 1+1+1>3 synergistic strategy is proposed and validated for the first time. Three homologous luminogens with aggregation-induced emission (AIE) characteristics were rationally designed based on a simple backbone. Through slight structural tuning, these far-red/near-infrared AIE luminogens are capable of specifically anchoring to mitochondria, cell membrane, and lysosome, and effectively generating reactive oxygen species (ROS). Notably, biological studies demonstrated combined usage of three AIE photosensitizers gives multiple ROS sources simultaneously derived from several organelles, which gives superior therapeutic effect than that from a single organelle at the same photosensitizers concentration. This strategy is conceptually and operationally simple, providing an innovative approach and renewed awareness of improving therapeutic effect through three-pronged PDT.

Compound with aggregation-induced emission property as well as preparation method and application thereof

The invention relates to a compound with aggregation-induced emission property as well as a preparation method and application thereof, the compound has a molecular structural formula, and R1 and R2 are respectively and independently selected from one of H and a group shown as the specification. The compound with the aggregation-induced emission property, provided by the invention, has relatively long absorption and emission wavelengths, the emission wavelength can reach a near-infrared light region, and the compound has efficient I-type ROS generation efficiency. The compound with the aggregation-induced emission property, provided by the invention, can be used for targeting tumor cell nucleus imaging after being wrapped by a cell nucleus targeting carrier to form nanoparticles. Therefore, the material can be used for tumor cell nucleus targeted photodynamic therapy.

AGGREGATION-INDUCED EMISSION LUMINOGENS FOR PHOTODYNAMIC THERAPY

Provided herein are aggregation-induced emission luminogens useful as photodynamic therapy and imaging agents, compositions including two or more aggregation-induced emission luminogens, pharmaceutical compositions comprising the same, and methods of use

Tunable NIR AIE-active optical materials for lipid droplet imaging in typical model organisms and photodynamic therapy

Near infrared (NIR) luminescent materials with aggregation-induced emission (AIE) features have attracted enormous attention in the areas of medical imaging and diagnostic therapeutics because of their low background fluorescence and strong tissue penetra

Near-infrared luminous triphenylamine derivative fluorescent molecule as well as preparation method and application thereof

The invention provides a near-infrared luminous triphenylamine derivative fluorescent molecule as well as a preparation method and application thereof. The structural formula of the triphenylamine derivative fluorescent molecule is shown as a formula I which is described in the specification. The near-infrared fluorescent molecule has relatively large Stokes displacement and near-infrared fluorescence emission signals; and besides, the preparation method of the molecule is simple and high in designability, can effectively guide the design and synthesis of near-infrared fluorescent functional molecule, and has important application prospects in the field of disease diagnosis and treatment. In the formula I, X is as shown in the specification.

Rational construction of AIEgens with wide color tunability and their specific lipid droplet imaging applications

Organic light-emitting materials with aggregation-induced emission (AIE) character have experienced a rapid development in imaging, visualization and sensing. In this paper, by installing rotors to an aggregation-caused quenching (ACQ) compound, we constructed an AIE luminogen (AIEgens) system (A2-A4, B1-B3) with wide emission tunability, which covers almost all regions of visible light (400-780 nm). The calculated energy gap of the compounds is consistent with the value of the absorption transition. In the biological experiments, B3 showed excellent lipid droplet (LD) targeting ability in PC12 cells, and higher photostability compared with the commercial LDs bioprobe. Moreover, as a hydrophobic compound, B3 can distinguish blood from a hyperlipidemia patient and normal people. Thus, this study provides a strategy to construct red/NIR fluorescent materials with AIE character, and further apply it to identify the blood of people with hyperlipidemia. This journal is

STILBENE AND FUSED STILBENE DERIVATIVES AS SOLAR CELL DYES

The present application discloses stilbene derivative compounds and phenyl- benzofuran compositions, useful in the manufacture of dye-sensitized solar cells and other similar technology.

STILBENE DERIVATIVES FOR THE TREATMENT OF CNS AND OTHER DISORDERS

The present application discloses stilbene derivative compounds and compositions, and methods for treating ocular diseases, neurological disorders and protein aggregation-related disorders in patients using the compounds and compositions as disclosed herein.