329032-88-4

Upstream product

• 329032-84-0 2'-O-azidomethyl-N⁶-benzoyl-3',5'-O-(1,1,3,3-tetraisopropyldisilox-1,3-diyl)adenosine 
• 139434-69-8 N-benzoyl-3′,5′-O-(1,1,3,3-tetraisopropyldisiloxane-1, 3-diyl)-2′-O-[(methylthio)methyl]adenosine 

Downstream Products

• 1203913-86-3 N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(azidomethyl)adenosine 

Relevant academic research and scientific papers

Synthesis of RNA by the rapid phosphotriester method using azido-based 2'-O-protecting groups

The azidomethyl and 2-(azidomethyl)benzoyl as 2'-OH protecting groups are reported for preparation of oligoribonucleotides by the phosphotriester solid-phase method using O-nucleophilic intramolecular catalysis. The procedures for the synthesis of the corresponding monomer synthons were developed and the usefulness of the application of 2'-O-azidomethyl and 2'-O-2-(azidomethyl) benzoyl groups was examined in the synthesis of different RNA fragments with a chain length of 15-22 nucleotides. The azidomethyl group was found to be more preferable for effective synthesis of oligoribonucleotides. Hybridization properties of RNAs toward their complementary oligonucleotides were examined before and after the removal of 2'-O-azidomethyl groups.

An azidomethyl protective group in the synthesis of oligoribonucleotides by the phosphotriester method

A rapid and effective method of an automatic oligoribonucleotide synthesis alternative to the phosphoramidite one was developed. This method is based on the phosphotriester approach to internucleotide bond formation under intramolecular O-nucleophilic cat

S, X-acetals in nucleoside chemistry. III1. Synthesis of 2′- and 3′-O-azidomethyl derivatives of ribonucleosides

2′- and 3′-O-azidomethyl derivatives of ribonucleosides were obtained by splitting the corresponding methylthiomethyl derivatives of ribonucleosides with bromine or SO2Cl2 followed by lithium azide treatment.