329069-71-8

Basic information

• Product Name: 2,5-dimethoxybenzaldehyde thiosemicarbazone
• Synonyms: 2,5-dimethoxybenzaldehyde thiosemicarbazone
• CAS NO: 329069-71-8
• Molecular Weight: 239.298
• Mol File: 329069-71-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2,5-dimethoxybenzaldehyde thiosemicarbazone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-dimethoxybenzaldehyde thiosemicarbazone(329069-71-8)
• EPA Substance Registry System: 2,5-dimethoxybenzaldehyde thiosemicarbazone(329069-71-8)

Safety Data

• Hazardous Substances Data: 329069-71-8(Hazardous Substances Data)

Upstream product

• 79-19-6 thiosemicarbazide 
• 93-02-7 2,5-dimethoxybenzaldehyde 

Downstream Products

• 88742-90-9 5-(2,5-dimethoxyphenyl)-1,3,4-thiadiazol-2-amine 

Relevant articles and documents

A mechanosynthesized, sequential, cyclic fluorescent probe for mercury and iodide ions in aqueous solutions

A fluorescent Hg2+-selective chemosensor, 2,5- dimethoxybenzaldehyde thiosemicarbazone (1), was quantitatively prepared by grinding 2,5-dimethoxybenzaldehyde and thiosemicarbazide together in a ball mill for 15 min. The excitation and emission maxima of compound 1 are 347 and 450 nm, respectively. The reaction of this ligand with Hg2+ was investigated by FT-IR, 1H NMR, and fluorescence titration. Results show that the composition of the resulting Hg complex 1-Hg is 2:1 1:Hg, and that the S and imino N atoms serve as the binding sites of the ligand to the Hg 2+ ions. Coordination-assisted fluorescence quenching results show that compound 1 exhibits a highly selective fluorescence response to trace amounts of Hg2+ in water. More importantly, the resulting complex 1-Hg can be used as a turn-on fluorescence probe for I- at a detection limit of 8.4 × 10-8 M. Thus, compound 1 is a relatively stable, sequential, cyclic fluorescent probe for Hg2+ and I-.

PhI-Catalyzed Intramolecular Oxidative Coupling Toward Synthesis of 2-Amino-1,3,4-Thiadizoles

A highly efficient method for the synthesis of thiadiazole derivatives via intramolecular oxidative coupling of thiosemicarbazide, using the in situ generated hypervalent iodine(III) reagents is developed. The protocol can be carried out smoothly and provides a variety of thiadiazole derivatives in moderate to excellent yields. Graphical Abstract: A highly efficient method for the synthesis of thiadiazole derivatives via PhI-catalyzed intramolecular oxidative coupling of thiosemicarbazide has been developed.