329185-67-3Relevant academic research and scientific papers
Functionalization of indole at C-5 or C-7 via palladium-catalysed double carbonylation. A facile synthesis of indole ketocarboxamides and carboxamide dimers
Takács, Attila,Marosv?lgyi-Haskó, Diána,Kabak-Solt, Zsuzsanna,Damas, Liliana,Rodrigues, Fábio M.S.,Carrilho, Rui M.B.,Pineiro, Marta,Pereira, Mariette M.,Kollár, László
, p. 247 - 256 (2016)
Palladium-catalysed aminocarbonylation of 7-iodoindole derivatives (the parent compound and 5-bromo-7-iodoindole), as well as 5-iodoindole with various primary and secondary amines, including amino acid esters and chiral diamines, was carried out. In this
Aminocarbonylation of aryl iodides with primary and secondary amines in aqueous medium using polymer supported palladium-N-heterocyclic carbene complex as an efficient and heterogeneous recyclable catalyst
Qureshi, Ziyauddin S.,Revankar, Santosh A.,Khedkar, Mayur V.,Bhanage, Bhalchandra M.
, p. 148 - 153 (2015/02/20)
Aminocarbonylation of aryl iodides with primary and secondary aromatic/aliphatic amines to corresponding amides using polymer supported palladium-N-heterocyclic carbene complex (PS-Pd-NHC) as an efficient heterogeneous, recyclable catalyst is described. The catalytic system was optimized with respect to various reaction parameters to give excellent yield of desired products. The catalyst can be easily separated by simple filtration process and recycled further up to four consecutive recycle without loss in any activity and selectivity. The protocol is advantageous due to the ease in handling of the catalyst, simple workup procedure, and environmentally benign water as solvent and effective catalyst recyclability.
NOVEL RHO KINASE INHIBITORS AND METHODS OF USE
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Page/Page column 87, (2012/10/18)
The subject invention concerns materials and methods for treating diseases and disorders associated with expression of Rho associated kinases (ROCKs). Examples of diseases and disorders contemplated within the scope of the invention include, but are not limited to, oncological disorders, cardiovascular diseases, CNS disorders, and inflammatory disorders. In one embodiment, a method of the invention comprises administering a therapeutically effective amount of one or more compounds of the present invention, or a composition comprising the compounds, to a person or animal in need of treatment. The subject invention also concerns compounds that inhibit ROCKs, and compositions that comprise the inhibitor compounds of the invention. Compounds contemplated within the scope of the invention include, but are not limited to, those compounds shown in Table (5).
Regioselective ortho-directed metalation and electrophilic substitution of indole- and indoline-5-(N-phenyl)carboxamides
Rousseau, Jean-Fran?ois,Dodd, Robert H.
, p. 2289 - 2304 (2007/10/03)
Treatment of 1-(N,N-dimethylsulfamoyl)-1H-indole-5-(N-phenyl) carboxamide (1) with s-butyllithium at -80°C in THF followed by addition of an electrophile gave exclusively the product of C-2 substitution. A second metalation-substitution cycle on this prod
Efficient electrochemical cleavage of N,N-dimethylaminosulfonyl-protected indoles
Largeron,Farrell,Rousseau,Fleury,Potier,Dodd
, p. 9403 - 9406 (2007/10/03)
Indoles protected at the N-1 position with the N,N-dimethylaminosulfonyl group were efficiently deprotected by electrolysis. Yields were in the 80-90% range and the method was compatible with a number of functional groups (nitrile, ester, chloride, carboxamide). (C) 2000 Elsevier Science Ltd.
