329222-98-2Relevant academic research and scientific papers
Direct observation (NMR) of the efficacy of glucagon receptor antagonists in murine liver expressing the human glucagon receptor
Cohen, Sheila M.,Duffy, Joseph L.,Miller, Corin,Kirk, Brian A.,Candelore, Mari Rios,Ding, Victor D. H.,Kaczorowski, Gregory,Tota, Laurie M.,Werrmann, Jeffrey G.,Wright, Michael,Parmee, Emma R.,Tata, James R.,Zhang, Bei B.
, p. 1506 - 1517 (2007/10/03)
The demonstration of pharmacodynamic efficacy of novel chemical entities represents a formidable challenge in the early exploration of synthetic lead classes. Here, we demonstrate a technique to validate the biological efficacy of novel antagonists of the
Discovery and investigation of a novel class of thiophene-derived antagonists of the human glucagon receptor
Duffy, Joseph L.,Kirk, Brian A.,Konteatis, Zenon,Campbell, Elizabeth L.,Liang, Rui,Brady, Edward J.,Candelore, Mari Rios,Ding, Victor D.H.,Jiang, Guoqiang,Liu, Frank,Qureshi, Sajjad A.,Saperstein, Richard,Szalkowski, Deborah,Tong, Sharon,Tota, Lauri M.,Xie, Dan,Yang, Xiaodong,Zafian, Peter,Zheng, Song,Chapman, Kevin T.,Zhang, Bei B.,Tata, James R.
, p. 1401 - 1405 (2007/10/03)
A novel class of antagonists of the human glucagon receptor (hGCGR) has been discovered. Systematic modification of the lead compound identified substituents that were essential for activity and those that were amenable to further optimization. This SAR e
