329314-75-2

Usage

Uses

Used in Organic Synthesis:
(2E)-2-(4-ethenyl-3-methyl-5-oxopyrrol-2-ylidene)acetamide is used as a building block in organic synthesis for the creation of various complex organic molecules. Its unique structure with a pyrrole ring and an acetamide group allows for versatile chemical reactions and the formation of diverse compounds.
Used in Pharmaceutical and Medicinal Chemistry:
(2E)-2-(4-ethenyl-3-methyl-5-oxopyrrol-2-ylidene)acetamide may have potential applications in pharmaceutical and medicinal chemistry due to its structural features. Its pyrrole ring and acetamide group can be utilized in the development of new drugs and therapeutic agents, although further research and investigation are required to explore its full potential in this field.

Upstream product

• 635-65-4 bilirubin IXα 
• 36284-06-7 bilirubin 

Relevant academic research and scientific papers

In vivo and in vitro identification of Z -BOX C-a new bilirubin oxidation end product

A new bilirubin oxidation end product (BOX) was isolated and characterized. The formation of the so-called Z-BOX C proceeds from bilirubin via propentdyopents as intermediates. This BOX was detected in pathological human bile samples using liquid chromatography/mass spectrometry and has potential relevance for liver dysfunction and cerebral vasospasms.

Total synthesis and detection of the bilirubin oxidation product (Z)-2-(3-ethenyl-4-methyl-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)ethanamide (Z-BOX A)

The selective total synthesis of the pure Z-isomer of BOX A (8a), a product of oxidative heme degradation with significant physiological impact, was achieved in four to six steps starting from 3-bromo-4-methylfuran-2,5-dione (1). Z-BOX A forms a strong hydrogen bridge framework in the crystalline state. LC-MS techniques allow identification and characterization of isomeric forms of BOX A.