329322-38-5Relevant academic research and scientific papers
Synthesis and cytotoxicity of dihydroartemisinin ethers containing cyanoarylmethyl group
Li, Ying,Wu, Jin-Ming,Shan, Feng,Wu, Guang-Shao,Ding, Jian,Xiao, Dong,Han, Jia-Xian,Atassi, Ghanem,Leonce, Stephane,Caignard, Daniel-Henri,Renard, Pierre
, p. 977 - 984 (2003)
A new type of ether of dihydroartemisinin containing cyano and aryl groups was prepared and tested for cytotoxicity to A549, P388, L1210 and HT29 cells using the MTT assay. 12k and 12l were the most cytotoxic compounds. 13 lacking the peroxy group showed a 1000-fold less potency than 12l. Similarly, the inactive compound 14 indicated that the position of cyano groups was also important. Flow cytometry data showed that the compounds caused an accumulation of P388 cells in the G1-phase of the cell cycle.
Novel antitumor artemisinin derivatives targeting G1 phase of the cell cycle
Li, Ying,Shan, Feng,Wu, Jin-Ming,Wu, Guang-Shao,Ding, Jian,Xiao, Dong,Yang, Wei-Yi,Atassi, Ghanem,Leonce, Stephane,Caignard, Daniel-Henri,Renard, Pierre
, p. 5 - 8 (2001)
Modification of artemisinin structure led us to the discovery of a novel class of antitumor compounds. These artemisinin derivatives containing cyano and aryl groups showed potent antiproliferative effect in vitro against P388 and A549 cells. This activit
