329329-49-9Relevant academic research and scientific papers
Asymmetric chemo- and regiospecific addition of organozinc reagents to Baylis-Hillman derived allylic electrophiles
Borner,Gimeno,Gladiali,Goldsmith,Ramazzotti,Woodward
, p. 2433 - 2434 (2000)
The copper-catalysed S(N)2' addition of ZnR2 to allylic (Z)-ArCH=C(CH2X)(CO2Et) (X = Br, Cl, OSO2Me) fashions only ArCH(R)C(=CH2)(CO2Et); use of a chiral ligand gives up to 64% ee for this
Expedient synthesis of β,β-disubstituted α- methylenepropionates
Biswas, Kallolmay,B?rner, Christoph,Gimeno, Josepe,Goldsmith, Paul J.,Ramazzotti, Daniella,So, Angela L.K.,Woodward, Simon
, p. 1433 - 1442 (2007/10/03)
Baylis-Hillman alcohols are excellent sources of the allylic halides ArCHCH(CH2X)(CO2R) (X=Br, Cl; R1=Me, Et, But). The Z double bond isomers are attained in high isomeric purity (>14:1, Z/E). The halides are ch
