329694-46-4

Usage

Thiadiazole ring

1,3,4-thiadiazol-2-yl

Amino group

5-amino

Thiol group

sulfanyl

Fluoro-substituted phenyl group

2-fluorophenyl

Potential pharmaceutical applications

Antibacterial properties
Antifungal properties
Building block for synthesis of other bioactive compounds

Further investigation needed

Precise biological activity
Potential uses in medicine

Upstream product

• 348-54-9 2-Fluoroaniline 
• 347-66-0 2-chloro-N-(2-fluorophenyl)acetamide 
• 2349-67-9 2-Amino-5-mercapto-1,3,4-thiadiazole 

Relevant academic research and scientific papers

Synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives incorporating benzisoselenazolone scaffold as potential antitumor agents

Background: Based on the biological signi-cance of benzisoselenazolone and 1,3,4-thiadiazole, a series of novel 1,3,4-thiadiazole derivatives incorporating benzisoselenazolone scaffold were designed and synthesized with ebselen as a lead compound. Methods: Meanwhile, their in vitro antitumor activities were evaluated against SMMC-7721, MCF-7 and A549 human cancer cell lines by CCK-8 assay. Results: The preliminary bioassay results demonstrated that all tested compounds 4a-q showed potent antitumor activities, and some compounds exhibited better effects than positive control ethaselen and 5-fluorouracil (5-FU) against various cancer cell lines. Furthermore, compounds 4b and 4m showed significant antitumor activities against SMMC-7721 cells with IC50 values of 1.89 and 1.89 μM, respectively. Compounds 4c and 4n displayed highly effective biological activities against MCF-7 cells with IC50 values of 2.88 and 2.28 μM, respectively. Compound 4i showed the best inhibitory effect against A549 cells with IC50 value of 1.76 μM. Conclusion: The pharmacological results suggest that the substituent groups of phenyl ring on the 1,3,4-thiadiazole are vital for modulating antitumor activities against various cancer cell lines.