329765-59-5

Upstream product

• 66432-69-7 1-bromomethyl-4-isopropenylcyclohexene 
• 119910-45-1 2-bromo-1H-indole-3-carbaldehyde 
• 329765-58-4 2-bromo-(4-isopropenyl-cyclohex-1-enylmethyl)-1H-indole-3-carbaldehyde 

Relevant academic research and scientific papers

2-Amidinylindole-3-carbaldehydes: Versatile synthons for the preparation of α-carboline derivatives

The 2-amidinylindole-3-carbaldehydes 1 are the key starting materials for the preparation of three classes of carbolines 2, 6 and 7 in which the pyridine ring is characterised by a different substitution patterns. The carbolines 2 which are functionalized with an amino group in position 2, were obtained directly by heating 1 in presence of SiO2. The condensation of amidines 1 with arylmethylketones afforded unsaturated ketones 5 which on heating were transformed into 2,9-dialkyl-3-aroyl-9H-pyrido[2,3-b]indoles 7. Instead, prolonged reaction of amidines 1 with arylmethylketones in t-BuOH/t-BuOK gave 2-aryl-9H-pyrido[2,3-b]indoles 6. (C) 2000 Elsevier Science Ltd.