329772-75-0

Upstream product

• 329772-80-7 N-trifluoroacetyl-1-(3,4-dimethoxy)benzyl-7-acetoxy-1,2,3,4,6,7-hexahydro-7-methoxy-6-oxoisoquinoline 
• 848574-81-2 2,2,2-trifluoro-1-[6-hydroxy-1-(2-iodo-4,5-dimethoxy-benzyl)-7-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-ethanone 
• 329772-68-1 N-trifluoroacetyl-1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-6-benzyloxy-7-methoxyisoquinoline 
• 329772-86-3 N-trifluoroacetyl-1-(3,4-dimethoxy)benzyl-8a-acetoxy-1,2,3,4,6,8a-hexahydro-7-methoxy-6-oxoisoquinoline 

Downstream Products

• 329772-80-7 N-trifluoroacetyl-1-(3,4-dimethoxy)benzyl-7-acetoxy-1,2,3,4,6,7-hexahydro-7-methoxy-6-oxoisoquinoline 

Relevant academic research and scientific papers

Synthesis of N-trifluoroacetyl-2-hydroxynoraporphine by radical reaction of p-quinol acetate of N-trifluoroacetyl-1-(2-iodoveratryl)methyl-1, 2, 3, 4-tetrahydro-7-methoxyisoquinolin-6-ol

Radical reaction of p-quinol acetate (8b) of N-trifluroroacetyl-1- (2-iodoveratryl)methyl-1, 2, 3, 4-tetrahydro-7-methoxyisoquinolin-6-ol (7b) using tributyltin hydride gave the corresponding noraporphine (9)(45%), while that of the bromo congener (8a) failed. Similar reaction of 8b using tris(trimethylsilyl)silane improved the yield (75%) of 9.

Formation and reaction of N-acyl- and N-methanesulfonyl-1-(3,4-dimethoxy)benzyl-7-acetoxy-1,2,3,4,6,7-hexahydro- 7-methoxy-6-oxoisoquinolines (o-quinol acetates)

Oxidation of N-acyl- and N-methanesulfonyl-1,2,3,4-tetrahydro-7-methoxyisoquinolin-6-ols (7) with lead tetraacetate in dichloromethane produced quantitatively title compounds (o-QAs) (8). Treatment of N-trifluoroacetyl and N-formyl o-QAs (8a,b) with aceti