329794-79-8Relevant academic research and scientific papers
Practical and scalable synthesis of orthogonally protected-2-substituted chiral piperazines
Chamakuri, Srinivas,Santini, Conrad,Shah, Manuj M.,Yang, David C. H.,Young, Damian W.
, p. 8844 - 8849 (2020/11/23)
A synthetic route to orthogonally protected, enantiomerically pure 2-substituted piperazines is described. Starting from α-amino acids, within four steps chiral 2-substituted piperazines are obtained. The key transformation involves an aza-Michael additio
