32988-39-9

Basic information

• Product Name: 3-NITRO-D-TYROSINE
• Synonyms: 3-NITRO-D-TYROSINE;H-D-TYR(3-NO2)-OH;H-D-TYR(M-NO2)-OH;H-3-NITRO-D-TYR-OH;D-(3-NITRO-4-HYDROXY)PHENYLALANINE;D-(3-NITRO)TYROSINE;(R)-2-AMINO-3-(4-HYDROXY-3-NITRO-PHENYL)-PROPIONIC ACID;(R)-2-amino-3-(4-hydroxy-3-nitrophenyl)propanoic acid
• CAS NO: 32988-39-9
• Molecular Formula: C₉H₁₀N₂O₅
• Molecular Weight: 226.19
• Mol File: 32988-39-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• Solubility: Aqueous Acid (Slightly), DMSO (Slightly, Heated), Sulfuric Acid (Slightly)
• CAS DataBase Reference: 3-NITRO-D-TYROSINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-NITRO-D-TYROSINE(32988-39-9)
• EPA Substance Registry System: 3-NITRO-D-TYROSINE(32988-39-9)

Safety Data

• Hazardous Substances Data: 32988-39-9(Hazardous Substances Data)

Usage

General Description

3-Nitro-D-Tyrosine, a derivative of the amino acid tyrosine, is a chemical compound often used in scientific research. Its molecular formula is C9H10N2O5 and it is a crystalline solid with a yellowish appearance. 3-NITRO-D-TYROSINE plays a significant role in biological studies as a biomarker to measure the levels of nitrosative stress in organisms. Due to its nitrated state, it indicates the presence of reactive nitrogen species which are involved in various physiological and pathophysiological processes. It is often employed in the study of neurodegenerative disorders, cardiovascular diseases, and cancer.

Upstream product

• 556-02-5 tyrosine 

Downstream Products

• 948576-00-9 C₁₀H₁₃NO₆S 

Relevant articles and documents

Inhibitory effect of isoflavones on peroxynitrite-mediated low-density lipoprotein oxidation.

Peroxynitrite, a potent oxidant formed in vivo from the reaction of nitric oxide with superoxide, can mediate low-density liprotein (LDL) oxidation which is thought to increase the risk of atherosclerosis. This study investigates the inhibitory effect of the isoflavones, genistein and daidzein, together with their glycosidic forms, genistin and daidzin, on the peroxynitrite-mediated LDL oxidation and nitration of tyrosine. Genistein and daidzein were observed to dose-dependently inhibit peroxynitrite-mediated LDL oxidation, while their glucoside conjugates showed less activity. Moreover, all the isoflavones used in this study were found to be potent peroxynitrite scavengers, preventing the nitration of tyrosine. The ability of the isoflavones at 50 microM to decrease the tyrosine nitration induced by peroxynitrite (1 mM) was in the ratios of genistein (49%), daidzein (40%), daidzin (41%) and genistin (42%) when compared to the control (tyrosine incubated only with peroxynitrite). These results suggest that an intake of isoflavones could contribute to protecting against cardiovascular diseases and chronic inflammatory diseases.