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32990-47-9

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32990-47-9 Usage

General Description

4-Methylthiophene-2-carbonyl chloride is a chemical compound with the molecular formula C6H5ClOS. It is an organochlorine compound that contains a thiophene ring and a carbonyl chloride group. 4-METHYLTHIOPHENE-2-CARBONYL CHLORIDE is mainly used in the synthesis of various pharmaceuticals, agrochemicals, and advanced materials. It is a reactive intermediate that can undergo various chemical reactions to form a wide range of derivatives. 4-Methylthiophene-2-carbonyl chloride is commonly employed as a building block in the pharmaceutical industry for the production of active pharmaceutical ingredients and is also utilized in the synthesis of other fine chemicals.

Check Digit Verification of cas no

The CAS Registry Mumber 32990-47-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,2,9,9 and 0 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 32990-47:
(7*3)+(6*2)+(5*9)+(4*9)+(3*0)+(2*4)+(1*7)=129
129 % 10 = 9
So 32990-47-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H5ClOS/c1-4-2-5(6(7)8)9-3-4/h2-3H,1H3

32990-47-9 Well-known Company Product Price

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  • Aldrich

  • (652040)  4-Methylthiophene-2-carbonylchloride  97%

  • 32990-47-9

  • 652040-5G

  • 1,205.10CNY

  • Detail
  • Aldrich

  • (652040)  4-Methylthiophene-2-carbonylchloride  97%

  • 32990-47-9

  • 652040-25G

  • 4,464.72CNY

  • Detail

32990-47-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-METHYLTHIOPHENE-2-CARBONYL CHLORIDE

1.2 Other means of identification

Product number -
Other names 2-(Chlorocarbonyl)-4-methylthiophene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:32990-47-9 SDS

32990-47-9Relevant articles and documents

A Series of Thiadiazolyl-Benzenesulfonamides Incorporating an Aromatic Tail as Isoform-Selective, Potent Carbonic Anhydrase II/XII Inhibitors

Banoglu, Erden,Bonardi, Alessandro,Gratteri, Paola,Supuran, Claudiu T.,Vullo, Daniela,Ercanl?, Taner,Gür Maz, Tu??e

, (2022/03/14)

We describe the synthesis of a series of thiadiazolyl-benzenesulfonamide derivatives carrying an aromatic tail linked by an amide linker (12–34), as human carbonic anhydrase (hCA) inhibitors. These thiadiazol derivatives were evaluated against four physiologically relevant CA isoforms (hCA I, II, IX, and XII), and demonstrated intriguing inhibitory activity against CA II with Ki values in the range of 2.4–31.6 nM. Besides hCA II, also hCA XII activity was potently inhibited by some of the derivatives (Ki=1.5–88.5 nM), producing dual inhibitors of both isoforms. Notably, compound 17 was the most potent dual CA II (Ki=3.1 nM) and XII (Ki=1.5 nM) inhibitor with a significant selectivity ratio over CA I and IX isoforms. In conclusion, although all compounds exhibited preferential activity towards hCA II, the nature of the substituents at the tail part of the main scaffold influenced the activity and selectivity toward other isoforms.

Design, synthesis and activity evaluation study of novel substituted N-sulfonyl homoserine lactone derivatives as bacterial quorum sensing inhibitors

Sun, Qi,Zhao, Mingming,Liang, Jingwei,Xiao, Junhai,Meng, Fanhao

, p. 3345 - 3353 (2017/11/16)

A novel series of N-sulfonyl homoserine lactone derivatives 7a–7m has been designed, synthesized, and evaluated for quorum sensing inhibitory activities through the violacein inhibition in Chromobacterium violaceum CV026. Compound 7e displayed the high level of inhibitory activity among all the compounds synthesized. Studies of structure-activity relationship indicated that compounds with thiophene group in side chain showed better activity than those substituted by furan, pyrrole, pyridyl, and phenethyl group. Thiophene substituted compounds which connected electron withdrawing group exhibited better inhibitory activity relate to those connected electron donating group. Further analysis indicated that compound bearing an electron withdrawing substituent at the position 2 of their thiophene ring exhibited superior activity against violacein production to those bearing the substituent at the position 3 and 4. Compound 7e in particular, with IC50 value of 6.19 μM, were identified as promising lead compounds for further development.

HIV Integrase Inhibitors

-

Page/Page column 30, (2010/11/29)

The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.

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