329909-29-7

Usage

Uses

Used in Pharmaceutical Industry:
3-Fluoro-4-methylbenzenesulfonamid is used as a building block for the synthesis of various biologically active compounds. Its unique structure with a fluorine atom and a methyl group allows for the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical industry, 3-Fluoro-4-methylbenzenesulfonamid serves as a key intermediate in the production of pesticides and other agrochemicals. Its chemical properties make it suitable for creating compounds that can effectively control pests and diseases in agriculture.
Used as a Reagent in Organic Synthesis:
3-Fluoro-4-methylbenzenesulfonamid is also utilized as a reagent in organic synthesis. Its ability to participate in various chemical reactions makes it a valuable tool for creating a wide range of organic compounds for different applications.
Used as an Intermediate in the Production of Fine Chemicals:
3-FLUORO-4-METHYLBENZENESULFONAMID& is used as an intermediate in the production of fine chemicals, which are high-purity chemicals used in various industries such as pharmaceuticals, fragrances, and flavors. Its role in the synthesis of these high-quality chemicals is crucial for maintaining their performance and effectiveness.

InChI:InChI=1/C7H8FNO2S/c1-5-2-3-6(4-7(5)8)12(9,10)11/h2-4H,1H3,(H2,9,10,11)

Upstream product

• 84363-11-1 6-fluoro-toluene-3-sulfonic acid 
• 90260-13-2 3-fluoro-4-methylbenzene-1-sulfonyl chloride 

Downstream Products

• 1078622-12-4 (2R,6S,13aS,14aR,16aS,Z)-6-(tert-butoxycarbonylamino)-14a-(3-fluoro-4-methyl-phenylsulfonylcarbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-cyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoro-isoindoline-2-carboxylate 
• 714968-42-0 4-(aminosulfonyl)-2-fluorobenzoic acid 

Relevant academic research and scientific papers

FLUORO-CONTAINING COMPOUNDS, USE AND PREPARATION THEREOF

The present teachings relate to a fluoro-containing compound, a composition thereof, a method of using the compound or the composition in treating a disease, and a method of preparing the compound. In a particular example, the compound is chosen from Form

Novel 4,4-disubstituted piperidine-based C-C chemokine receptor-5 inhibitors with high potency against human immunodeficiency virus-1 and an improved human ether-a-go-go related gene (hERG) profile

We recently described (J. Med. Chem. 2008, 51, 6538-6546) a novel class of CCR5 antagonists with strong anti-HIV potency. Herein, we detail SAR converting leads 1 and 2 to druglike molecules. The pivotal structural motif enabling this transition was the secondary sulfonamide substituent. Further finetuning of the substituent pattern in the sulfonamide paved the way to enhancing potency and bioavailability and minimizing hERG inhibition, resulting in discovery of clinical compound 122 (GSK163929).

PROCESS FOR MAKING N-SULFONATED-AMINO ACID DERIVATIVES

This invention relates to a process for preparing optically active α -amino acid substrates which are used to make potent lethal factor (LF) inhibitors for the treatment of anthrax. This invention further relates to a process for synthesis of potent LF-inhibitors for the treatment of anthrax. Specifically, the invention concerns a novel, high-yielding and highly enantioselective asymmetric hydrogenation reaction of a tetrasubstituted ene-sulfonamide acid or ester.

CCR5 ANTAGONISTS AS THERAPEUTIC AGENTS

The present invention relates to compounds of formula (I) or pharmaceutically acceptable derivatives thereof, useful in the treatment or prophylaxis of CCR5-related diseases and disorders, for example, in the inhibition of HIV replication, the prevention or treatment of an HIV infection, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS).