329924-39-2

Upstream product

• 141-43-5 ethanolamine 
• 150727-73-4 4-tert-butyl-N-[6-chloro-2-cyclopropyl-5-(2-methoxy-phenoxy)-pyrimidin-4-yl]-benzenesulfonamide 
• 329924-27-8 4,6-dichloro-5-(2-methoxyphenoxy)-2-cyclopropyl-pyrimidine 

Relevant academic research and scientific papers

Bis-sulfonamides as endothelin receptor antagonists

Modification of the structure of bosentan 1, the first marketed endothelin receptor antagonist (Tracleer), by introduction of a second sulfonamide function at the alkoxy side chain, led to bis-sulfonamides 2. This allowed to prepare dual ETA/ETB as well as ETB receptor selective antagonists, which could serve as tools to investigate the pharmacological consequences of selective ETB receptor blockade.