329966-07-6

Upstream product

• 857390-29-5 3-(2,6-dimethoxyphenoxy)propane-1,2-diol 
• 91-10-1 1,3-dimethoxy-2-hydroxy-benzene 
• 60827-45-4 (S)-3-chloropropan-1,2-diol 
• 329966-06-5 (2R)-3-(2,6-dimethoxyphenoxy)-1,2-propanediol acetonide 

Downstream Products

• 329966-09-8 (2R)-3-(2,6-dihydroxyphenoxy)-1,2-bis(tosyloxy)propane 
• 329966-13-4 (2S)-2-((tosyloxy)methyl)-5-methoxy-1,4-benzodioxane 
• 329966-11-2 (2S)-2-((tosyloxy)methyl)-5-hydroxy-1,4-benzodioxane 
• 329966-08-7 (2R)-3-(2,6-dimethoxyphenoxy)-1,2-bis(tosyloxy)propane 

Relevant academic research and scientific papers

Crystallization features and spontaneous resolution of 3-(2,6-dimethoxyphenoxy)propane-1,2-diol: The case of stable conglomerate and metastable solid solution

Phase behavior of 3-(2,6-dimethoxyphenoxy)propane-1,2-diol 1 was investigated by IR spectroscopy, X-ray diffraction, and DSC methods. Racemic diol 1 prone to spontaneous resolution and has been resolved into (S)- and (R)-enantiomers by a preferential crystallization procedure. Separation takes place, but it gives crystalline precipitates with moderate (60–70%) enantiomeric excess values. The plausible reason is the formation of metastable phase of solid solution during the crystallization.