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2-Chloro-2,2-difluoro-N-phenylacetamide is a chemical compound with the molecular formula C8H6ClF2NO. It is a derivative of acetamide, featuring a chloro and two fluoro substituents on the acetamide backbone, as well as a phenyl group attached to the nitrogen atom. 2-chloro-2,2-difluoro-N-phenylacetamide is known for its potential applications in pharmaceuticals and agrochemicals, particularly as an intermediate in the synthesis of various active ingredients. Due to its unique structure, it exhibits specific chemical properties, such as reactivity towards nucleophiles and electrophiles, which can be exploited in various chemical transformations. The compound is typically synthesized through a series of reactions involving the substitution of hydrogen atoms in the acetamide molecule with chlorine and fluorine atoms, followed by the introduction of the phenyl group. It is important to handle 2-chloro-2,2-difluoro-N-phenylacetamide with care due to its potential toxicity and reactivity, and it is often used in research and development settings to explore new chemical pathways and applications.

330-73-4

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330-73-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 330-73-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,3 and 0 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 330-73:
(5*3)+(4*3)+(3*0)+(2*7)+(1*3)=44
44 % 10 = 4
So 330-73-4 is a valid CAS Registry Number.

330-73-4Downstream Products

330-73-4Relevant academic research and scientific papers

Palladium-catalyzed intramolecular C-H difluoroalkylation: Synthesis of substituted 3,3-difluoro-2-oxindoles

Shi, Shi-Liang,Buchwald, Stephen L.

, p. 1646 - 1650 (2015)

The synthesis of 3, 3-difluoro-2-oxindoles through a robust and efficient palladium-catalyzed C-H difluoroalkylation is described. This process generates a broad range of difluorooxindoles from readily prepared starting materials. The use of BrettPhos as the ligand was crucial for high efficiency. Preliminary mechanistic studies suggest that oxidative addition is the rate-determining step for this process.

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