3300-16-1

Upstream product

• 157757-99-8 9-tert-butyl-9-(chloromethyl)fluorene 

Downstream Products

• 93651-44-6 9-methyl-9-(2-hydroxy-2-propyl)fluorene 
• 62731-52-6 9-Methylfluoren-9-carbonsaeureethylester 
• 82102-37-2 9-methyl-9H-fluorene-9-carbonyl chloride 
• 3274-88-2 toluene-4-sulfonic acid-(9-methyl-fluoren-9-ylmethyl ester) 

Relevant academic research and scientific papers

Medicaments for inhalation comprising a novel anticholinergic and a steroid

A pharmaceutical composition comprising a compound of formula 1 wherein X? is an anion with a single negative charge, and a betamimetic, optionally together with a pharmaceutically acceptable excipient, the compound of formula 1 and the betamimetic optionally in the form of their enantiomers, mixtures of their enantiomers, their racemates, their solvates, or their hydrates, processes for preparing them, and their use in the treatment of respiratory tract diseases.

Carbanions 27. Rearrangements of (9-alkyl-9-fluorenyl)-methyllithium (or cesium) and 2,2-diphenyl-3,3-dimethyl-butyllithium

A study has been made upon the products from warming various (9-alkyl-9-fluorenyl)methyllithium (or cesium) compounds in THF to near 0°C followed by carbonation. When the 9-alkyl group is ethyl, the result is chiefly the protonated product (9-alkyl-9- fluorenyl)methane; a similar product evidently is formed when the 9-alkyl group is 1-norbornyl. When the 9-alkyl group is tert-butyl, the minor product is 9-neopentylfluorene-9-carboxylic acid from a [1,2]-migration of the tert-butyl group while the major product is 9-methylfluorene-9-carboxylic acid from an intramolecular elimination as shown by deuterium labeling. When the 9-alkyl is neopentyl, the major product is 9-neopentyl-9,10-dihydro-phenanthrene-9-carboxylic acid along with some 9-neopentylphenanthrene which becomes the major product in diethyl ether solution at 35°C. 2,2-Diphenyl-3,3-dimethylbutyllithium undergoes predominantly [1,2]-phenyl migration in THF at 0°C. From an x-ray crystal study upon 9-tert-butyl-9-(chloromethyl)fluorene and 9-neopentyl-9-(chloromethyl) fluorene, it is concluded that steric acceleration is responsible for the unusual reactions of (9-alkyl-9-fluorenyl)methyllithiums when the 9-alkyl groups are tert-butyl and neopentyl.