330151-22-9

Upstream product

• 20881-04-3 1,2:3,5-di-O-isopropylidene-D-xylofuranose 
• 532-20-7 α-D-xylofuranose 
• 20031-21-4 1,2-O-isopropylidene-α-D-xylose 
• 35387-59-8 1,2-Bis(phenylsulfonyl)ethylene 

Downstream Products

• 943856-01-7 1,2-di-O-acetyl-3,5-O-(2-phenylsulfonyl)ethylidene-D-xylofuranose 
• 1353644-97-9 1,2-O-isopropylidene-5-O-[(E)-2'-(phenylsulfonyl)vinyl]-α-D-xylofuranose 
• 1353644-99-1 5-O-tert-butyldimethylsilyl-1,2-O-isopropylidene-3-O-[(E)-2'-(phenylsulfonyl)vinyl]-α-D-xylofuranose 
• 20031-21-4 1,2-O-isopropylidene-α-D-xylose 
• 943856-03-9 C₁₉H₂₀N₂O₉S 
• 943856-02-8 C₂₀H₂₁N₅O₇S 
• 943856-04-0 C₂₆H₂₅N₃O₉S 

Relevant academic research and scientific papers

Probing of PSE acetal protection for nucleoside chemistry

The use of phenylsulfonylethylidene (PSE) acetal as a new 3′,5′-bridged protecting group in nucleoside chemistry is reported. The PSE acetal demonstrates to be compatible with Lewis acids used in standard glycosylation reactions. In addition, a selective 2′-O-deacylation from a 3′,5′-O-(phenylsulfonyl)-2′-O-acetyl nucleoside can be achieved, giving access to subsequent chemical modifications in 2′ position. However, the PSE acetal cleavage surprisingly appeared to be purine/pyrimidine base dependent.

Phenylsulfonylethylidene (PSE) acetals: A novel protective group in carbohydrate chemistry

A range of sugar-derived phenylsulfonylethylidene acetals were easily obtained from the corresponding diols and 1,2-bis(phenylsulfonyl)ethylene under basic conditions. Deprotection methods for such acetals have also been investigated.

Phenylsulfonylethylidene (PSE) acetals as atypical carbohydrate- protective groups

We introduce a new class of arylsulfonylated cyclic acetals derived from carbohydrate structures which are synthesized with high yields under basic conditions. Deprotection methods for such acetals are also investigated. (C) 2000 Elsevier Science Ltd.