330161-87-0 Usage
Uses
Used in Cancer Research:
SU 6656 is used as a selective inhibitor for the Src family of proto-oncogenic kinases in cancer research. It helps in understanding the role of these kinases in cell growth, development, and carcinogenesis.
Used in Pharmaceutical Industry:
SU 6656 is used as a small molecule selective inhibitor of the Src kinase family to induce caspase-independent cancer cell death, potentially leading to the development of novel cancer treatments.
Used in Cell Growth and Development Studies:
SU 6656 is used as a research tool to study the role of Src kinases in diverse processes such as nervous system development and fibrosis, providing insights into the underlying mechanisms and potential therapeutic targets.
Biochem/physiol Actions
Cell permeable: yes
in vivo
su6656 administered prior to irradiation significantly promotes radiation-induced destruction of blood vessels within the tumor windows. it also facilitates tumor growth delay when administered during fractionated irradiation. [3]
references
1. blake ra, broome ma, liu x et al. su6656, a selective src family kinase inhibitor, used to probe growth factor signaling. mol cell biol. 2000 dec;20(23):9018-27.2. lannutti bj, blake n, gandhi mj et al. induction of polyploidization in leukemic cell lines and primary bone marrow by src kinase inhibitor su6656. blood. 2005 may 15;105(10):3875-8.3. cuneo kc, geng l, tan j et al. src family kinase inhibitor su6656 enhances antiangiogenic effect of irradiation. int j radiat oncol biol phys. 2006 mar 15;64(4):1197-203.
Check Digit Verification of cas no
The CAS Registry Mumber 330161-87-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,3,0,1,6 and 1 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 330161-87:
(8*3)+(7*3)+(6*0)+(5*1)+(4*6)+(3*1)+(2*8)+(1*7)=100
100 % 10 = 0
So 330161-87-0 is a valid CAS Registry Number.
InChI:InChI=1/C19H21N3O3S/c1-22(2)26(24,25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,3-6H2,1-2H3,(H,21,23)/b16-10-
