33017-40-2

Upstream product

• 620151-96-4 (S)-ethyl N-(2-phenylcyclopropanecarbonyl)-4,4-dimethylpyroglutamate 
• 939-87-7 2-phenyl-1-cyclopropanecarbonyl chloride 

Relevant academic research and scientific papers

Chemoselective Nucleophilic Attack on N-Acyl Derivatives of (S)-Ethyl 4,4-Dimethyl Pyroglutamate (DMPG)

(Matrix presented) Heteronucleophiles and C-nucleophiles chemoselectively react with N-acyl (S)-ethyl 4,4-dimethyl pyroglutamate (DMPG) affording esters, amides, and ketones in high yield. The intramolecular process allows the stereoselective formation of β-hydroxy acids likely by formation and ring opening of the corresponding β-lactones.