33035-62-0Relevant academic research and scientific papers
Isolation and characterization of atropisomers of seven-membered-ring benzolactams
Tabata, Hidetsugu,Wada, Naoya,Takada, Yuko,Oshitari, Tetsuta,Takahashi, Hideyo,Natsugari, Hideaki
scheme or table, p. 5123 - 5131 (2011/08/06)
The atropisomeric properties of seven-membered-ring benzolactams (7a-c and 8a) [1,5-benzodiazepin-2-one (a), 1,5-benzothiazepin-4-one (b), and 1-benzazepin-2-one (c)] were examined. The atropisomers were isolated as the diastereomers with an (S)-phenethyl
Clozapine derived 2,3-dihydro-1H-1,4- and 1,5-benzodiazepines with D4 receptor selectivity: Synthesis and biological testing
Hussenether, Thomas,Huebner, Harald,Gmeiner, Peter,Troschuetz, Reinhard
, p. 2625 - 2637 (2007/10/03)
Novel 4-arylpiperazin-1-yl-substituted 2,3-dihydro-1H-1,4- and 1H-1,5-benzodiazepines and their aza-analogues were synthesized as debenzoclozapine derivatives for evaluation as potential D4-ligands. While Ki values of some of the title compounds came within the range of clozapine, they showed an impressively greater selectivity over other dopamine receptor subtypes, especially D2. For the most promising compounds, intrinsic activity and binding properties to serotonin 5-HT1A and 5-HT2 were also determined.
