33042-66-9

Usage

Uses

Used in Medicinal Chemistry:
SPIRO[INDENE-1,4'-PIPERIDINE] is used as a valuable scaffold for the design of biologically active molecules due to its spirocyclic nature and unique molecular structure.
Used in Drug Discovery:
In the field of drug discovery, SPIRO[INDENE-1,4'-PIPERIDINE] is utilized as a versatile building block for the synthesis of novel pharmaceuticals, potentially leading to the development of new therapeutic agents.
Used in Organic Synthesis:
SPIRO[INDENE-1,4'-PIPERIDINE] is also employed in organic synthesis, where its distinct properties and conformational flexibility contribute to the creation of diverse chemical entities with potential applications in various industries.

Upstream product

• 95-13-6 1-indene 
• 137419-24-0 1'-(tert-butyloxycarbonyl)spiro<1H-indene-1,4'-piperidine> 

Downstream Products

• 691875-95-3 C₂₉H₃₆N₂O₄ 
• 691875-98-6 C₂₄H₂₆BrNO₂ 
• 1309436-19-8 ethyl (3S)-3-[4-[[5-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)-2-thienyl]methoxy]phenyl]hex-4-ynoate 
• 1309435-60-6 (3S)-3-[4-[[5-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)-2-thienyl]methoxy]phenyl]hex-4-ynoic acid 
• 1416435-96-5 5-isoxazoyl-Cha-Ile-spiro[1H-indene-1,4'-piperidine] 
• 878232-02-1 1-benzyloxycarbonyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-piperidine)-1-ylpropyl]-D-prolineamide 
• 878231-90-4 1-benzyloxycarbonyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-piperidine)-1-ylpropyl]-L-prolineamide 

Relevant academic research and scientific papers

A class of GPR40 agonist compounds with amide structure, and uses thereof

The present invention relates to a class of amide compounds with a novel structure, and a pharmaceutical composition thereof, wherein the structure of the amide compound is represented by a general formula (I). According to the present invention, the amide compound (I) can regulate GPR40 activity, and can be used for GPR40 activity related diseases such as diabetes and metabolic syndrome. The formula I is defined in the specification.

Compound as potassium channel modulator

The invention relates to a compound as a potassium channel modulator, which is a compound of a formula (I) or a pharmaceutically acceptable salt thereof. The compound or the pharmaceutically acceptable salt thereof is effective for curing and preventing diseases and symptoms influenced by the activity of potassium ion channels.

SUBSTITUTED HETEROCYCLIC DERIVATIVES AS GPR AGONISTS AND USES THEREOF

The present invention generally relates to substituted heterocyclic derivatives (the compounds of Formula (I)), processes for their preparation, pharmaceutical compositions containing said compounds, their use as G-protein coupled receptor (GPR) agonists, particularly as GPR40 agonists and methods of using these compounds in the treatment of GPR40 mediated diseases or conditions such as Type 2 diabetes, obesity, dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

NOVEL SPIRO COMPOUND AND MEDICINE COMPRISING THE SAME

It is to provide a novel compound useful for preventing and/or treating diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome. A spiro compound represented by the following general for

INDOL-3-YL-CARBONYL-SPIRO-PIPERIDINE DERIVATIVES AS V1A RECEPTOR ANTAGONISTS

The invention relates to indol-3-yl-carbonyl-spiro-piperidine derivatives which act as V1a receptor antagonists and which are represented by Formula I: wherein the spiro-piperidine head group A and the residues R1, R2 and R3 are as defined herein. The invention further relates to pharmaceutical compositions containing such compounds, methods for preparing the compounds and pharmaceutical compositions, and their use in the treatment of dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder, anxious and depressive disorders.

SPIROCYCLIC ANTIPSYCHOTIC AGENTS

A class of spirocyclic piperidine derivatives are selective ligands at sigma recognition sites and are therefore useful in the treatment and/or prevention of psychiatric disorders.