330444-59-2Relevant academic research and scientific papers
Tandem ene-reaction/Intramolecular Sakurai Cyclisation (IMSC): A novel access to polysubstituted tetrahydropyrans and γ-butyrolactones using a unique allylation strategy
Marko, Istvan E.,Dumeunier, Raphael,Leclercq, Cedric,Leroy, Bernard,Plancher, Jean-Marc,Mekhalfia, Abdelaziz,Bayston, Daniel J.
, p. 958 - 972 (2002)
The ene-reaction between a variety of aldehydes and allylsilane 22 generates highly functionalised homoallylic alcohols 23. These adducts undergo a subsequent Intramolecular Sakurai Cyclisation (IMSC), affording in good yields polysubstituted tetrahydropyran derivatives. Furthermore, oxidative desilylation of 23 provides an efficient, connective access to a range of γ-butyrolactones and α-methylene-γ-butyrolactones.
Concise and connective synthesis of exo-methylene-γ-butyrolactones
Dumeunier, Rapha?l,Leclercq, Cédric,Markó, István E
, p. 2307 - 2311 (2007/10/03)
A novel sequence, combining an ene-reaction of the substituted allylsilane 2 with a variety of aldehydes, followed by an oxidative double desilylation, provides an efficient access to a wide range of exo-methylene-γ-butyrolactones.
