330467-50-0Relevant academic research and scientific papers
Photoinduced Carbamoylation of C(sp3)H Bonds with Isocyanates
Ishida, Naoki,Kawasaki, Tairin,Murakami, Masahiro,Tomono, Ryota,Yamazaki, Katsushi
supporting information, p. 1684 - 1684 (2021/09/16)
Alkylbenzenes coupled with isocyanates at the benzylic position upon irradiation with visible light in the presence of an iridium photoredox catalyst, a bromide anion, and a nickel catalyst, producing N-substituted α-aryl amides. An analogous carbamoylation reaction of aliphatic CH bonds of alkanes took place when UV light and a diaryl ketone were used instead of visible light and the iridium complex. The present reaction offers a straightforward and atom-economical method for the synthesis of carboxamides starting from hydrocarbons with one-carbon extension.
SO42-/CexZr1-xO2-catalyzed synthesis of N-tert-butylamides from various nitriles under solvent-free conditions
Kahandal, Sandeep S.,Kale, Sandip R.,Disale, Shamrao T.,Jayaram, Radha V.
experimental part, p. 738 - 740 (2012/09/22)
The synthesis of N-tert-butylamides using SO4 2-/CexZr1-x O2 catalysts under solvent-free conditions is reported. The methodology has several advantages such as reusability of the catalyst, solvent-free conditions, easy workup, and comparable yield of N-tert-butylamides. A variety of aliphatic, aromatic, and acid-sensitive substrates give high to moderate yields of the corresponding N-tert-butylamides. Surface acidities of the catalysts were correlated with the results obtained. To the best of our knowledge, this is the first report of a modified Ritter reaction on SO42-/CexZr1-x O2 using tert-butyl acetate as carbocationic source.
Palladium-catalyzed amidation of N-tosylhydrazones with isocyanides
Zhou, Fengtao,Ding, Ke,Cai, Qian
experimental part, p. 12268 - 12271 (2011/11/29)
Aminocarbonylation of N-tosylhydrazones: The direct formation of ketenimines from carbenes and isocyanides is limited to the reaction of Fischer carbene complexes or some specially stabilized carbenes with isocyanides. A Pd-catalyzed amidation of N-tosylhydrazones with isocyanides via a ketenimine intermediate in the presence of water is described. The method offers a general way to synthesize amides from carbonyl compounds through one-carbon extension (see scheme). Copyright
Stereoselective synthesis of 3,4-diaryl β-lactams
Troisi, Luigino,Pindinelli, Emanuela,Strusi, Valentina,Trinchera, Piera
experimental part, p. 368 - 374 (2009/07/25)
Novel 3,4-diaryl β-lactams were prepared with high stereoselectivity in an efficient manner by a palladium-catalyzed [2+2] carbonylative cycloaddition of benzyl halides with heteroarylidene amines. The type of alkyl group linked to the nitrogen atom influences the reaction's stereoselectivity. Moreover, using chiral imines, separable diastereomeric mixtures of chiral 3,4-diaryl-β-lactams were isolated with good yields and high trans diastereoselections.
