33049-08-0

Basic information

• Product Name: L-A-GLYCEROPHOSPHORYLETHANOLAMINE*FROM E COLI
• Synonyms: L-A-GLYCEROPHOSPHORYLETHANOLAMINE*FROM E COLI;L-a-Glycerophosphorylethanolamine (anhydrous) (GPE);(-)-1-O-[(2-Aminoethyl)phosphono]-D-glycerol;[R,(-)]-D-Glycerol 1-[phosphoric acid (2-aminoethyl)] ester;2-[(L-Glycero-3-phospho)oxy]ethaneamine;O-(L-Glycero-3-phospho)-2-aminoethanol;O-[[[(2R)-2,3-Dihydroxypropyl]oxy]phosphonyl]-2-aminoethanol;sn-Glycero-3-phhosphoethanolamine
• CAS NO: 33049-08-0
• Molecular Formula: C5H14 N O6 P
• Molecular Weight: 215.14
• Mol File: 33049-08-0.mol

Chemical Properties

• Boiling Point: 436.7±55.0 °C(Predicted)
• Appearance: /
• Density: 1.488±0.06 g/cm3(Predicted)
• PKA: 1.15±0.50(Predicted)
• CAS DataBase Reference: L-A-GLYCEROPHOSPHORYLETHANOLAMINE*FROM E COLI(CAS DataBase Reference)
• NIST Chemistry Reference: L-A-GLYCEROPHOSPHORYLETHANOLAMINE*FROM E COLI(33049-08-0)
• EPA Substance Registry System: L-A-GLYCEROPHOSPHORYLETHANOLAMINE*FROM E COLI(33049-08-0)

Safety Data

• Hazardous Substances Data: 33049-08-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
L-α-Glycerophosphorylethanolamine is used as a therapeutic agent for neurological disorders due to its potential to modulate cellular processes and improve membrane integrity, thereby offering neuroprotective effects.
Used in Oncology:
In the field of oncology, L-α-Glycerophosphorylethanolamine is utilized for its potential role in cancer treatment. Its involvement in lipid metabolism may contribute to the regulation of cellular processes that could impact tumor growth and progression.
Used in Biochemical Research:
L-α-Glycerophosphorylethanolamine is employed as a research tool in biochemical studies to understand its role in cell membrane formation and lipid metabolism, furthering our knowledge of its biological functions and potential applications in medicine.
Used in Drug Development:
As a compound with potential therapeutic applications, L-α-Glycerophosphorylethanolamine is used in drug development for the creation of novel pharmaceuticals targeting neurological disorders and cancer, leveraging its biological properties for therapeutic benefits.

Relevant articles and documents

A Simple and Efficient Method for Synthesis of sn-Glycero-Phosphoethanolamine

An efficient three-step strategy for the convenient synthesis of Sn-glycero-3-phosphoethanolamine (GroPEtn) from a commercially available 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE) is reported. Direct hydrolysis of DPPE produces a complex inseparable mixture, hence a protection and deprotection strategy is employed to prepare GroPEtn. The primary amine of DPPE is protected with a highly stable acid-labile trityl group, followed by strong base hydrolysis of N-trityl-DPPE gives N-trityl-GroPEtn. Further a mild, rapid, and efficient deprotection method is established using trifluoroacetic acid to remove N-trityl moiety, affords GroPEtn as a single product. This is the first semisynthetic approach and efficient method to produce GroPEtn with a total yield of 66% in three steps. GroPEtn did not show any cytotoxicity against human kidney (HK-2) cells and reporter gene assay for activation of Keap1-Nrf2-mediated antioxidant defense mechanism showed no significant effects.