33050-38-3

Usage

Uses

Used in Pharmaceutical Industry:
3,6-Dichloro[1,2,4]triazolo[4,3-b]pyridazine is used as a key building block in the synthesis of various pharmaceutical drugs. Its unique structure and chemical properties make it a valuable component in drug discovery and development, contributing to the creation of new therapeutic agents.
Used in Medicinal Chemistry Research:
3,6-Dichloro[1,2,4]triazolo[4,3-b]pyridazine is utilized as a valuable tool in medicinal chemistry research, where its reactivity and structural features are harnessed to explore novel drug design approaches and enhance the understanding of molecular interactions.
Used in Drug Design:
3,6-Dichloro[1,2,4]triazolo[4,3-b]pyridazine's structure makes it potentially useful in the development of new therapeutic agents, as it can be incorporated into drug molecules to modulate their properties and improve their efficacy in treating various diseases.

InChI:InChI=1/C5H2Cl2N4/c6-3-1-2-4-8-9-5(7)11(4)10-3/h1-2H

Upstream product

• 28593-24-0 6-chloro[1,2,4]triazolo[4,3-b]pyridazine 
• 17284-97-8 3-Chloro-6-hydrazinopyridazine 
• 541-41-3 chloroformic acid ethyl ester 
• 33050-32-7 6-chloro-[1,2,4]-triazolo[4,3-b]pyridazin-3-ol 
• 33050-32-7 6-chloro-1,2,4-triazolo[4,3-b]pyridazin-3(2H)-one 
• 158607-17-1 3-(2,3-dibromomethylenehydrazino)-6-chloropyridazine 
• 158607-16-0 6-chloro-3-methylenehydrazinopyridazine 
• 7197-01-5 6-chloro-3-methyl-1,2,4-triazolo<4,3-b>pyridazine 

Downstream Products

• 1429024-67-8 6-(4'-fluorobiphenyl-2-yloxy)-3-chloro-[1,2,4]triazolo[4,3-b]pyridazine 
• 1429024-70-3 6-(2',4'-difluorobiphenyl-2-yloxy)-3-chloro-[1,2,4]triazolo[4,3-b]pyridazine 
• 1429025-61-5 5-(2-(3-chloro-[1,2,4]triazolo[4,3-b]pyridazin-6-yloxy)-4-(trifluoromethyl)phenyl)-N,N-dimethylpyridin-2-amine 
• 1429025-06-8 3-chloro-6-(4-acetamidobiphenyl-2-yloxy)-[1,2,4]triazolo[4,3-b]pyridazine 
• 1429025-29-5 3-chloro-6-(4-trifluoromethyl-3'-aminocarbonylbiphenyl-2-yloxy)-[1,2,4]triazolo[4,3-b]pyridazine 
• 1429025-35-3 3-chloro-6-(2-(2-fluoropyridin-3-yl)-5-(trifluoromethyl)phenoxy)-[1,2_,4]triazolo[4,3-b]pyridazine 
• 1429025-60-4 3-chloro-6-(2-(6-chloropyridin-3-yl)-5-(trifluoromethyl)phenoxy)-[1,2,4]triazolo[4,3-b]pyridazine 
• 1429024-44-1 6-(biphenyl-3-yloxy)-3-chloro-[1,2,4]triazolo[4,3-b]pyridazine 
• 1429025-62-6 3-chloro-6-(2-(thiazol-4-yl)phenoxy)-[1,2,4]triazolo[4,3-b]pyridazine 
• 1429025-81-9 3-chloro-6-(2-(morpholinomethyl)-5-(trifluoromethyl)phenoxy)-[1,2,4]triazolo[4,3-b]pyridazine 
• 1429025-88-6 3-chloro-6-(2-(pyridin-3-yl)-3-(trifluoromethyl)phenoxy)-[1_.2_.4]triazolo[4,3-b]pyridazine 
• 1429025-72-8 3-chloro-6-{[4-methoxy-3'-(trifluoromethyl)biphenyl-2-yl]oxy}-[1,2,4]triazolo[4,3-b]pyridazine 
• 1429025-77-3 3-chloro-6-(4'-chloro-5-fluorobiphenyl-2-yloxy)-[1,2,4]triazolo[4,3-b]pyridazine 
• 1429025-82-0 3-chloro-6-(2-(2-methylpyridin-3-yl)-5-(trifluoromethyl)phenoxy)-[1,2,4]triazolo[4,3-b]pyridazine 

Relevant academic research and scientific papers

HETEROAROMATIC COMPOUNDS AS PI3 KINASE MODULATORS AND METHODS OF USE

The present invention provides heteroaromatic derivatives and pharmaceutical acceptable salts and formulations thereof useful in modulating the protein kinase activity, especially phosphatidylinositol 3-kinases (PI3 kinases) and mTOR, and in modulating inter- and/or intra-cellular signaling activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

DERIVATIVES OF 6-SUBSTITUTED TRIAZOLOPYRIDAZINES AS REV-ERB AGONISTS

The present invention provides novel 6-substituted [1,2,4]triazolo[4,3-b]pyridazines that are agonists of Rev-Erb. These compounds, and pharmaceutical compositions comprising the same, are suitable means for treating any disease wherein the activation of Rev-Erb has therapeutic effects, for instance in inflammatory and circadian rhythm-related disorders or cardiometabolic diseases.

Synthesis and Reactivity of some 1,2,4-Triazolopyridazine Derivatives

The triazolopyridazine derivatives were obtained in the reaction of 3-chloro-6-hydrazinopyridazine with acetic acid and ethyl chloroformate.Acting on 6-chloro-3-methyl-1,2,4-triazolopyridazine with phosphorus pentachloride, a methyl group in position 3 has unexpectedly been exchanged by chlorine.The mechanism of fusing the triazole ring to the pyridazine system has been studied by the reaction of 3-chloro-6-hydrazinopyridazine with formaldehyde, acetaldehyde, and treatment the resulting Schiff bases by bromine in acetic acid with sodium acetate added.Key words: 1,2,4-Triazolopyridazines, nucleophilic substitution, cyclization mechanism