33063-48-8Relevant academic research and scientific papers
Preparation of Diorganomagnesium Reagents by Halogen-Lithium Exchange of Functionalized Heteroaryl Halides and Subsequent in situ Trapping with MgCl 2·liCl in Continuous Flow
Knochel, Paul,Nishimura, Rodolfo Hideki Vicente,Weidmann, Niels
, p. 3036 - 3046 (2020)
A halogen-lithium exchange in the presence of MgCl 2·LiCl on a broad range of heterocyclic scaffolds using a commercial flow set-up with n BuLi as exchange reagent is reported. The resulting diheteroarylmagnesium species were subsequently trapped with various electrophiles, such as ketones, aldehydes, allylic bromides, or disulfides affording functionalized heterocycles. A scale-up was performed by simply increasing the run-time without further optimizations.
