330680-95-0Relevant articles and documents
A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activity
Magrioti, Victoria,Naxakis, George,Hadjipavlou-Litina, Dimitra,Makriyannis, Alexandros,Kokotos, George
scheme or table, p. 5424 - 5427 (2009/05/26)
A variety of long chain 1,2-diamines and related compounds were synthesized and tested for their activity on fatty acid amide hydrolase (FAAH) and monoacyglycerol lipase (MGL). (2S,9Z)-Octadec-9-ene-1,2-diamine selectively inhibits MGL (Ki 21.8μ M) without significantly affecting FAAH. This compound exhibited interesting in vivo analgesic and anti-inflammatory properties, suggesting that selective inhibitors of MGL may be valuable novel agents for the treatment of inflammatory pain.