3307-41-3

Basic information

• Product Name: 2-(3,4-dichlorophenoxy)propanoic acid
• Synonyms: 2-(3,4-Dichlorophenoxy)propionic acid;2-(3,4-DP);3,4-DP
• CAS NO: 3307-41-3
• Molecular Formula: C₉H₈Cl₂O₃
• Molecular Weight: 235.06
• Mol File: 3307-41-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 353.5°Cat760mmHg
• Flash Point: 167.6°C
• Appearance: /
• Density: 1.421g/cm³
• Vapor Pressure: 1.31E-05mmHg at 25°C
• Refractive Index: 1.56
• CAS DataBase Reference: 2-(3,4-dichlorophenoxy)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-dichlorophenoxy)propanoic acid(3307-41-3)
• EPA Substance Registry System: 2-(3,4-dichlorophenoxy)propanoic acid(3307-41-3)

Safety Data

• Hazardous Substances Data: 3307-41-3(Hazardous Substances Data)

Usage

Classification

Synthetic auxin herbicide

Function

Controls broadleaf weeds in agricultural and residential settings by mimicking the natural plant hormone auxin, causing uncontrolled growth and eventual death of unwanted plants

Toxicity to Humans and Animals

Relatively low

Health and Environmental Concerns

Associated with potential harm to non-target plants and animals, possible carcinogenic effects

Usage History

Widely used since the 1940s, but restricted in some countries

Advantages

Effective and low cost

InChI:InChI=1/C9H8Cl2O3/c1-5(9(12)13)14-6-2-3-7(10)8(11)4-6/h2-5H,1H3,(H,12,13)

Upstream product

• 39975-26-3 sodium 3,4-dichlorophenoxide 
• 535-11-5 Ethyl 2-bromopropionate 
• 95-77-2 3,4-dichlorophenol 
• 598-72-1 2-Bromopropionic acid 

Downstream Products

• 81414-04-2 2-(3,4-Dichloro-phenoxy)-propionyl chloride 
• 92446-84-9 (R)-2-methyl-2-(3,4-dichlorophenoxy)ethanol 
• 92446-85-0 (S)-(+)-2-methyl-2-(3,4-dichlorophenoxy)ethanol 
• 33995-27-6 (R)-2-methyl-2-(3,4-dichlorophenoxy)acetic acid 
• 33995-26-5 (2S)-2-(3,4-dichlorophenoxy)propanoic acid 

Relevant articles and documents

Presynaptic cholinergic modulators as potent cognition enhancers and analgesic drugs. 2. 2-Phenoxy-, 2-(phenylthio)-, and 2-(phenylamino)alkanoic acid esters

Further modifications of the leads ((R)-(+)-hyoscyamine and (p- chlorophenyl)propionic acid α-tropanyl ester), which show analgesic and nootropic activities as a consequence of increased central presynaptic ACh release, are reported. 2-Phenoxy- and 2-(phenylthio)alkanoic acid esters showed the best results. Several members of these classes possess analgesic properties which are comparable to that of morphine and at the same time are able to reverse dicyclomine-induced amnesia. Confirmation was found that the mechanism of action is due to an increase in ACh release at central muscarinic synapses and that both auto- and heteroreceptors controlling ACh release are very likely involved. According to the results obtained with (R)- (+)-hyoscyamine, analgesic activity is stereochemistry dependent, since the R-(+)-enantiomers are always more efficacious than the corresponding S-(-)- ones. On the basis of their potency and acute toxicity, compounds (±)-28 (SM21) and (±)-42 (SM32) were selected for further study.