330800-50-5Relevant academic research and scientific papers
Asymmetric 1,4-reductions of and 1,4-additions to enoates and related systems
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, (2008/06/13)
One aspect of the present invention relates to methods for the transition-metal-catalyzed asymmetric 1,4-addition of a nucleophile, e.g., hydride, to cyclic and acyclic enoates and enones. In certain embodiments of the methods of the present invention, th
Dynamic kinetic resolution via asymmetric conjugate reduction: Enantio- and diastereoselective synthesis of 2,4-dialkyl cyclopentanones
Jurkauskas, Valdas,Buchwald, Stephen L.
, p. 2892 - 2893 (2007/10/03)
Herein, we report the kinetic and the dynamic kinetic resolutions of racemic 3,5-dialkyl-2-cyclopenten-1-ones. Kinetic resolution, with good selectivity factors (25-52), was achieved by conjugate reduction with catalytic CuCl/NaOt-Bu/(S)-p-tol-BINAP and s
