330830-99-4Relevant academic research and scientific papers
Polymorphs of 1-(5-methylthiazol-2-yl)-3-phenylthiourea and various anion-assisted assemblies of two positional isomers
Phukan, Nithi,Baruah, Jubaraj B.
, p. 2640 - 2653 (2014)
Orientations of the phenyl group and the intramolecular hydrogen bond play prime roles in the packing patterns of three conformational polymorphs of an unsymmetrical thiourea derivative, 1-(5-methylthiazol-2-yl)-3-phenylthiourea (PTH1). Self-assembly of e
Arene diruthenium(II)-mediated synthesis of imines from alcohols and amines under aerobic condition
Tamilthendral, Veerappan,Ramesh, Rengan,Malecki, Jan Grzegorz
, (2020/12/15)
The utility and selectivity of the newly synthesized dinuclear arene Ru(II) complex were demonstrated towards the synthesis of imines from coupling of alcohols and amines in the aerobic condition. Analytical and various spectral methods have been used to establish the unprecedented formation of the new thiolato-bridged dinuclear ruthenium complex. The molecular structure of the titled complex was evidenced with aid of X-ray crystallographic technique. A wide range of imines were obtained in good-to-excellent yields up to 98% and water as the by-product through an acceptorless dehydrogenative coupling of alcohols with amines. The catalytic reaction operated a concise atom economical without any oxidant with 1 mol% of the catalyst load. Further, the role of base, solvent and catalyst loading of the coupling reaction has been investigated. A plausible mechanism has been described and was found to proceed via the formation of an aldehyde intermediate. Short synthesis of antibacterial drug N-(salicylidene)-2-hydroxyaniline illustrated the utility of the present protocol.
