33089-16-6

Basic information

• Product Name: 2-phenyl-4-chloro-5-cyanopyrimidine
• Synonyms: 2-phenyl-4-chloro-5-cyanopyrimidine
• CAS NO: 33089-16-6
• Molecular Weight: 215.642
• Mol File: 33089-16-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-phenyl-4-chloro-5-cyanopyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-4-chloro-5-cyanopyrimidine(33089-16-6)
• EPA Substance Registry System: 2-phenyl-4-chloro-5-cyanopyrimidine(33089-16-6)

Safety Data

• Hazardous Substances Data: 33089-16-6(Hazardous Substances Data)

Upstream product

• 618-39-3 benzamidin 
• 27058-48-6 4-hydroxy-2-phenylpyrimidine-5-carbonitrile 
• 27058-48-6 6-oxo-2-phenyl-1,6-dihydro-pyrimidine-5-carbonitrile 

Downstream Products

• 33089-19-9 5-amino-2-phenyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester 
• 33089-20-2 5-amino-2-phenyl-thieno[2,3-d]pyrimidine-6-carboxylic acid anilide 
• 33140-73-7 7-phenyl-3H-thieno[2,3-d;4,5-d']dipyrimidin-4-one 
• 33097-08-4 2-methyl-7-phenyl-pyrimido[5',4':4,5]thieno[3,2-d][1,3]oxazin-4-one 
• 33097-09-5 3-(2-methoxy-ethyl)-2-methyl-7-phenyl-3H-thieno[2,3-d;4,5-d']dipyrimidin-4-one 
• 85386-15-8 2-phenylpyrimidine-5-carbonitrile 
• 122773-99-3 4-Ethoxy-2-phenyl-5-pyrimidincarbonsaeureethylester 
• 122773-98-2 5-carbamoyl-4-ethoxy-2-phenylpyrimidine 
• 122774-01-0 4-methoxy-5-cyano-2-phenylpyrimidine 
• 122774-03-2 4-Methoxy-2-phenyl-pyrimidine-5-carboximidic acid methyl ester; hydrochloride 
• 33089-21-3 5-amino-2-phenyl-thieno[2,3-d]pyrimidine-6-carboxylic acid naphthalen-2-ylamide 

Relevant articles and documents

Discovery of wtRET and V804MRET Inhibitors: From Hit to Lead

Oncogenic activation of RET kinase has been found in several neoplastic diseases, like medullary thyroid carcinoma, multiple endocrine neoplasia, papillary thyroid carcinoma, and non-small-cell lung cancer. Currently approved RET inhibitors were not originally designed to be RET inhibitors, and their potency against RET kinase has not been optimized. Hence, novel compounds able to inhibit both wild-type RET (wtRET) and its mutants (e.g., V804MRET) are needed. Herein we present the development and the preliminary evaluation of a new sub-micromolar wtRET/V804MRET inhibitor, N-(2-fluoro-5-trifluoromethylphenyl)-N′-{4′-[(2′′-benzamido)pyridin-4′′-ylamino]phenyl}urea (69), endowed with a 4-anilinopyridine structure, starting from our previously identified 4-anilinopyrimidine hit compound. Profiling against a panel of kinases indicated 69 as a multi cKIT/wtRET/V804MRET inhibitor.