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N-cyclohexyloxycarbonyl-alanine, also known as N-Cbz-alanine, is a chemical compound derived from the amino acid alanine. It is a protected form of alanine, where the amino group is substituted with a cyclohexyloxycarbonyl (Cbz) group. This modification is commonly used in peptide synthesis to prevent unwanted side reactions and to control the reactivity of the amino acid. The Cbz group can be removed under mild acidic conditions, allowing for the subsequent coupling of the deprotected alanine with other amino acids to form peptides. N-Cbz-alanine is a white crystalline solid and is an important building block in the synthesis of various peptides and proteins.

3309-46-4

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3309-46-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 3309-46-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,3,0 and 9 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 3309-46:
(6*3)+(5*3)+(4*0)+(3*9)+(2*4)+(1*6)=74
74 % 10 = 4
So 3309-46-4 is a valid CAS Registry Number.

3309-46-4Downstream Products

3309-46-4Relevant academic research and scientific papers

Cyclohexyloxycarbonyl based orthogonal solid phase peptide synthesis in Boc chemistry

Mezo, Gabor,Mihala, Nikolett,Koczan, Gyoergy,Hudecz, Ferenc

, p. 6757 - 6766 (2007/10/03)

Application of N-cyclohexyloxocarbonyl (Choc) protection in Boc chemistry on solid phase provides a new possibility for the preparation of protected peptide fragments. A Choc/OcHex protection scheme allows also the assembly of cyclic lactam peptides linked to the resin through the C- terminus. Choc protection is stable under the 1M TMSOTf-thioanisole/TFA cleavage condition at 0°C, but it is removable by anhydrous HF. We have utilized cyclohexyloxycarbonyl as an orthogonal protecting group for the synthesis of a i) bicyclic epitope peptide of glycoprotein D of HSV 1 on BHA resin and ii) fully protected hexapeptide involved in protein transport on Merrifield resin.

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