330935-85-8Relevant articles and documents
Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes
Michellys,Ardecky,Chen,Crombie,Etgen,Faul,Faulkner,Grese,Heyman,Karanewsky,Klausing,Leibowitz,Liu,Mais,Mapes,Marschke,Reifel-Miller,Ogilvie,Rungta,Thompson,Tyhonas,Boehm
, p. 2683 - 2696 (2007/10/03)
Previous data have shown that RXR-selective agonists (e.g., 3 and 4) are insulin sensitizers in rodent models of non-insulin-dependent diabetes mellitus (NIDDM). Unfortunately, they also produce dramatic increases in triglycerides and profound suppression