330940-40-4Relevant academic research and scientific papers
Benzamides and related inhibitors of factor Xa
-
Page/Page column 270-271, (2015/09/22)
Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.
Anthranilamide-based N,N-dialkylbenzamidines as potent and orally bioavailable factor Xa inhibitors: P4 SAR
Zhang, Penglie,Bao, Liang,Fan, Jingmei,Jia, Zhaozhong J.,Sinha, Uma,Wong, Paul W.,Park, Gary,Hutchaleelaha, Athiwat,Scarborough, Robert M.,Zhu, Bing-Yan
scheme or table, p. 2186 - 2189 (2010/02/28)
Anthranilamide-based benzamidine compound 4 and its N-substituted analogs were designed and examined as factor Xa inhibitors using substituted benzamidines as unconventional S4 binding element. A group of N,N-dialkylbenzamidines (11, 17 and 24) have been
