33097-53-9Relevant academic research and scientific papers
Lipoxygenase inhibitors, IV: Synthesis and cyclization reactions of open-chain N1-aryl-substituted amidrazones
Frohberg,Kupfer,Stenger,Baumeister,Nuhn
, p. 505 - 516 (2007/10/02)
α-Carbonyl carboxylic acid arylhydrazonochlorides obtained by Japp-Klingemann reaction are the starting substances for the synthesis of α-carbonyl carboxylic acid arylhydrazonoamides, -esters and -thioesters. The inhibiting activity of these compounds against 15- and 5-lipoxygenase is described. Reactions of derivatives of amidrazones with formaldehyde give triazole, triazoline and unexpected benzotriazepine derivatives.
