330970-71-3Relevant academic research and scientific papers
Synthesis and membrane binding properties of a lipopeptide fragment from influenza virus A hemagglutinin
Eisele, Frank,Kuhlmann, Juergen,Waldmann, Herbert
, p. 3362 - 3376 (2007/10/03)
Hemagglutinin from influenza virus A is a S-palmitoylated lipoglycoprotein in which the lipid groups are thought to influence the interaction between cell membrane and capsid during budding of viral offspring as well as fusion processes of the viral membr
Synthesis and membrane-binding properties of a characteristic lipopeptide from the membrane-anchoring domain of influenza virus A hemagglutinin
Eisele, Frank,Kuhlmann, Jrgen,Waldmann, Herbert
, p. 369 - 373 (2007/10/03)
On the trail of the influenza virus! Fluorescent-labeled lipopeptides, such as the characteristic S-palmitoylated partial structure from influenza virus hemagglutinin A (see picture), can be synthesized efficiently by employing a new enzymatic protecting-group technique in the key steps. Their binding to model membranes was determined in a kinetic assay, so leading to a first approximation of the membrane-anchoring ability of the corresponding lipopeptide motif in the parent protein.
