33098-13-4

Basic information

• Product Name: 4-(4,5-DICHLORO-6-OXOPYRIDAZIN-1(6H)-YL)BENZENESULFONAMIDE
• Synonyms: 4-(4,5-Dichloro-6-oxopyridazin-1-yl)benzenesulfonamide;4-(4,5-Dichloro-6-oxopyridazin-1(6H)-yl)benzenesulfonamide
• CAS NO: 33098-13-4
• Molecular Formula: C₁₀H₇Cl₂N₃O₃S
• Molecular Weight: 320.15
• Mol File: 33098-13-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 483.4 °C at 760 mmHg
• Flash Point: 246.1 °C
• Appearance: /
• Density: 1.72 g/cm³
• Vapor Pressure: 1.69E-09mmHg at 25°C
• Refractive Index: 1.709
• CAS DataBase Reference: 4-(4,5-DICHLORO-6-OXOPYRIDAZIN-1(6H)-YL)BENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4,5-DICHLORO-6-OXOPYRIDAZIN-1(6H)-YL)BENZENESULFONAMIDE(33098-13-4)
• EPA Substance Registry System: 4-(4,5-DICHLORO-6-OXOPYRIDAZIN-1(6H)-YL)BENZENESULFONAMIDE(33098-13-4)

Safety Data

• Hazardous Substances Data: 33098-13-4(Hazardous Substances Data)

Usage

General Description

4-(4,5-DICHLORO-6-OXOPYRIDAZIN-1(6H)-YL)BENZENESULFONAMIDE is a chemical compound with a molecular formula C12H8Cl2N4O3S. It is a sulfonamide derivative containing a pyridazine ring with chloro and oxo substituents. 4-(4,5-DICHLORO-6-OXOPYRIDAZIN-1(6H)-YL)BENZENESULFONAMIDE is commonly used in medicinal chemistry as an antifolate antibiotic, as well as in the development of potential drugs for the treatment of various diseases. It has shown promise in inhibiting the growth of a variety of cancer cells, making it a potential candidate for cancer therapy. Additionally, its sulfonamide moiety lends itself to potential interactions with various biological targets, making it a versatile compound with potential applications in pharmaceutical research and development.

InChI:InChI=1/C10H7Cl2N3O3S/c11-8-5-14-15(10(16)9(8)12)6-1-3-7(4-2-6)19(13,17)18/h1-5H,(H2,13,17,18)

Upstream product

• 87-56-9 mucochloric acid 
• 17852-52-7 4-hydrazinobenzene-1-sulfonamide hydrochloride 

Relevant articles and documents

Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines

An expanded set of pyridazine-containing benzene sulfonamides was investigated for inhibition of four human carbonic anhydrase isoforms, which revealed a pronounced inhibition trend toward hCA IX, a cancer-related, membrane-bound isoform of the enzyme. Comparison of antiproliferative effects of these compounds against cancer (PANC-1) and normal (ARPE-19) cells at 50 μM concentration narrowed the selection of compounds to the eight which displayed selective growth inhibition toward the cancer cells. More detailed investigation in concentration-dependent mode against normal (ARPE-19) and two cancer cell lines (PANC-1 and SK-MEL-2) identified two lead compounds one of which displayed a notable cytotoxicity toward pancreatic cancer cells while the other targeted the melanoma cells. These findings significantly expand the knowledge base concerning the hCA IX inhibitors whose inhibitory potency against a recombinant enzyme translates into selective anticancer activity under hypoxic conditions which are aimed to model the environment of a growing tumor.