331-05-5

Upstream product

• 2966-50-9 silver trifluoroacetate 
• 103-80-0 phenylacetyl chloride 
• 103-82-2 phenylacetic acid 
• 407-25-0 trifluoroacetic anhydride 
• 1555-80-2 phenylacetic anhydride 

Downstream Products

• 3966-97-0 3-benzyl-7-chloro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide 
• 93534-10-2 3-benzyl-6,8-dichloro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide 
• 3377-89-7 t-butyl phenylperacetate 
• 918331-44-9 17β-methyl-16β-phenyl-17α-phenylacetoxy-D-homoandrost-4,6-diene-3,17a-dione 
• 1187323-13-2 4-cyclohexyltetralen-2-ol phenylacetate 
• 1254803-06-9 4-cyclohexyl-3,4-dihydronaphthalen-2(1H)-one 

Relevant academic research and scientific papers

Clean-chemistry synthesis of 2-tetralones in a single-stage acylation - Cycloalkylation process

The preparation of substituted-2-tetralones by direct reaction of a 1-alkene with a substituted phenylacetic acid in a reaction system of trifluoroacetic anhydride (TFAA) and phosphoric acid is described. This single-stage process involves in situ formation of a mixed anhydride of the phenylacetic acid and acylation of the alkene by this species followed by cycloalkylation of the aromatic ring. This is a cleaner approach to the synthesis of 2-tetralones compared to Friedel-Crafts aliphatic acylation-cycloalkylation in that use of thionyl chloride, aluminum trichloride, and a chlorinated hydrocarbon solvent is eliminated. In addition, the atom efficiency is augmented by recovery of the spent TFAA as trifluoroacetic acid (TFA) and conversion of this back to TFAA by dehydration.

New-D-homoandrost-4,6-diene derivatives as potent progesterone receptor antagonist

The aim of this study was to synthesize three different D-homoandrostadiene derivatives (2-4) and study their biological activity. We carried out in vivo and in vitro experiments using female cycling mice, which were synchronized for estrus with luteinizi

THERAPEUTIC COMPOUNDS

The invention relates to protein binding interacting/binding compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating 5-HT2C and/or RSK disorders, including diseases and dis

New synthesis of tert-butyl peroxycarboxylates

tert-Butyl peroxyacetate, tert-butyl peroxybutyrate, tert-butyl phenylperoxyacetate, and tert-butyl peroxyundecanoate were obtained in nearly quantitative yields by the esterification of the corresponding carboxylic acids with tert-butyl hydroperoxide in the presence of trifluoroacetic anhydride and pyridine in nonaqueous medium at 0-5°C. No tert-butyl peroxytrifluoroacetate was formed as a by-product during the process. A possible reaction mechanism is discussed. Pleiades Publishing, Inc., 2006.

Acylation of Ferrocene and a 1,1′-Diphosphaferrocene with Acyl Trifluoroacetates in the Presence of Trifluoromethanesulfonic (Triflic) Acid or Some Metal Triflates

Ferrocene and 3,3′,4,4′-tetramethyl-1,1′ -diphosphaferrocene undergo efficient acylation by acyl trifluoroacetates (prepared in situ from carboxylic acids and trifluoroacetic anhydride) in the presence of an excess of trifluoromethanesulfonic acid or cata

Heterolytic decarboxylation involving acyltrifluoroacetyl peroxide intermediates

Selective carboxylic acid decarboxylation was elaborated. Generation of acyltrifluoroacetyl peroxides from carboxylic peracids and trifluoroacetyl anhydride (Method A), as well as from trifluoroperacetic acid and acyltrifluoroacetyl anhydride (Method B), leads to simultaneous peroxide decomposition into the corresponding alkyltrifluoroacetates. DFT computations, as well as experimental data, support an acid-catalyzed heterolytic mechanism for acyltrifluoroacetyl peroxide decomposition.