331-63-5

Basic information

• Product Name: 2-Fluoro-4-methoxybenzyl chloride
• Synonyms: 2-FLUORO-4-METHOXYBENZYL CHLORIDE;1-(Chloromethyl)-2-fluoro-4-methoxybenzene, 4-(Chloromethyl)-3-fluoroanisole, alpha-Chloro-2-fluoro-4-methoxytoluene;1-(Chloromethyl)-2-fluoro-4-methoxybenzene
• CAS NO: 331-63-5
• Molecular Formula: C₈H₈ClFO
• Molecular Weight: 174.6
• Product Categories: Fluorine series
• Mol File: 331-63-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 110-112°C/7mm
• Flash Point: 84.1°C
• Appearance: /
• Density: 1.22
• Vapor Pressure: 0.217mmHg at 25°C
• Refractive Index: 1.499
• CAS DataBase Reference: 2-Fluoro-4-methoxybenzyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-4-methoxybenzyl chloride(331-63-5)
• EPA Substance Registry System: 2-Fluoro-4-methoxybenzyl chloride(331-63-5)

Safety Data

• Hazard Codes: C
• Hazardous Substances Data: 331-63-5(Hazardous Substances Data)

Usage

General Description

2-Fluoro-4-methoxybenzyl chloride is a chemical compound that belongs to the class of organic compounds known as benzyl chlorides. It is a fluorinated derivative of benzyl chloride and contains both a fluoro group and a methoxy group attached to a benzene ring. 2-Fluoro-4-methoxybenzyl chloride is commonly used as a reagent in chemical reactions for the synthesis of various organic compounds. It is also used in the pharmaceutical and agrochemical industries for the production of active ingredients. 2-Fluoro-4-methoxybenzyl chloride is a versatile compound with a wide range of applications in organic synthesis and chemical industries.

InChI:InChI=1/C8H8ClFO/c1-11-7-3-2-6(5-9)8(10)4-7/h2-4H,5H2,1H3

Upstream product

• 331-64-6 2-fluoro-4-methoxy-benzaldehyde 
• 74457-86-6 1-(2-fluoro-4-methoxyphenyl)-1-ethanone 
• 394-42-3 2-fluoro-4-methoxy-benzoic acid 
• 456-49-5 1-fluoro-3-methoxybenzene 
• 405-09-4 (2-fluoro-4-methoxyphenyl)methanol 
• 321-24-4 2-Fluor-4-methoxybenzoesaurechlorid 

Downstream Products

• 428-81-9 acetylamino-(2-fluoro-4-methoxy-benzyl)-malonic acid diethyl ester 

Relevant articles and documents

Magnesiate-Utilized/Benzyne-Mediated Approach to Indenopyridones from 2-Pyridones: An Attempt to Synthesize the Indenopyridine Core of Haouamine

An efficient, short-staged synthesis of cis-fused indeno[2,1-b]- and indeno[1,2-c]pyridin-2-ones, starting from 2-pyridones, using magnesiates of type R3MgLi as nucleophilic and deprotonation agents, mediated by benzyne generated in situ, under optimized conditions, is described. Following the developed protocol, rare C4a-arylsubstituted indeno[2,1-b]pyridones, resembling the core of haouamine, were obtained. The protocol offering the one-pot synthesis directly from 2-pyridone is also described.

Isoindoline derivative and intermediate, preparation method, pharmaceutical composition and application thereof

The invention discloses an isoindoline derivative, and an intermediate, a preparation method, a pharmaceutical composition and application thereof. The isoindoline derivative of the invention and the pharmaceutical composition thereof can adjust productio

PYRIMIDINE-5-CARBOXAMIDE COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF

A compound of the formula wherein R1 is a heterocycle having a skeleton consisting of 3 to 15 atoms including 1 to 5 nitrogen atom(s), which heterocycle is attached by a secondary nitrogen atom constituting the heterocycle; X is an oxygen atom, a nitrogen atom optionally substituted by a hydrocarbon group having 1 to 5 carbon atom(s) or a sulfur atom optionally oxidized with 1 or 2 oxygen, Y is a bond or a C1-5 alkylene group, R2 is (1) a hydrogen atom, (2) a hydroxy group, (3) a C1-5 alkoxy group, (4) a C1-5 alkylthio group, (5) a carbocycle having 3 to 15 carbon atoms or (6) a heterocycle having a skeleton consisting of 3 to 15 atoms including 1 to 5 heteroatom(s), provided that when Y is a bond, R2 is a carbocycle having 3 to 15 carbon atoms or a heterocycle having a skeleton consisting of 3 to 15 atoms including 1 to 5 heteroatom(s) and; one of R3 and R4 is a hydrogen atom or a group of the formula: -Z-R5 (Z is a bond or C1-10 alkylene group optionally having substituent(s) and R5 is (1) a hydrogen atom, (2) a hydroxy group, (3) a C1-5 alkoxy group, (4) a nitrile group, (5) a C1-5 alkoxy-carbonyl group, (6) a carboxyl group, (7) a carbamoyl group, (8) a (mono or di-C1-5 alkyl)carbamoyl group, (9) an amino group, (10) a (di or mono-C1-5 alkyl)amino group, (11) a (C1-5 alkoxy-carbonyl)amino group, (12) a C1-5 alkylthio group, (13) a carbocycle having 3 to 15 carbon atoms or (14) a heterocycle having a skeleton consisting of 3 to 15 atoms including 1 to 5 heteroatom(s)); the other is a group of the formula: -Z-R5 (Z and R5 are as defined above); and R3 and R4 may form, together with the adjacent nitrogen atom, a heterocycle having a skeleton consisting of 3 to 15 atoms, which heterocycle is attached by a secondary nitrogen atom constituting the heterocycle, wherein the above-mentioned heterocycle and a carbocycle having 3 to 15 carbon atoms are each optionally substituted by substituent(s) selected from the group consisting of C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C7-16 aralkyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, C6-14 aryl, C1-8 alkoxy, C1-3 alkylenedioxy, hydroxy, halogen atom, amino, (di or mono-C1-5 alkyl)amino, (C1-5 alkoxy-carbonyl)amino, (C1-5 acyl)amino, (C1-5 acyl) (C1-5 alkyl)amino, C1-5 alkylthio, nitrile, nitro, C1-5 alkoxy-carbonyl, carboxyl, C1-5 alkyl-carbonyloxy, oxo, thioxo, C1-6 acyl group, sulfamoyl and (di or mono-C1-5 alkyl)sulfamoyl, or a salt thereof or a prodrug thereof have a superior cGMP specific phosphodiesterase (PDE) inhibitory activity, and can be used as an agent for the prophylaxis or treatment of cardiovascular diseases such as angina pectoris, heart failure, cardiac infarction, hypertension, arteriosclerosis and the like, allergic diseases such as asthma, or disorders of male or female genital function and the like.