331-63-5

Usage

Uses

Used in Organic Synthesis:
2-Fluoro-4-methoxybenzyl chloride is used as a reagent in chemical reactions for the synthesis of various organic compounds. Its unique structure allows for the creation of a diverse range of molecules, making it a valuable component in the development of new chemical entities.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Fluoro-4-methoxybenzyl chloride is used as a key intermediate in the production of active pharmaceutical ingredients. Its presence in the molecular structure can impart specific properties to the final drug, such as improved solubility, stability, or bioavailability.
Used in Agrochemical Industry:
2-Fluoro-4-methoxybenzyl chloride also finds application in the agrochemical industry, where it is utilized in the synthesis of active ingredients for pesticides and other agricultural chemicals. Its incorporation into these compounds can enhance their effectiveness and selectivity, leading to better crop protection and management.

InChI:InChI=1/C8H8ClFO/c1-11-7-3-2-6(5-9)8(10)4-7/h2-4H,5H2,1H3

Upstream product

• 405-09-4 (2-fluoro-4-methoxyphenyl)methanol 
• 456-49-5 1-fluoro-3-methoxybenzene 
• 394-42-3 2-fluoro-4-methoxy-benzoic acid 
• 331-64-6 2-fluoro-4-methoxy-benzaldehyde 
• 74457-86-6 1-(2-fluoro-4-methoxyphenyl)-1-ethanone 
• 321-24-4 2-Fluor-4-methoxybenzoesaurechlorid 

Downstream Products

• 428-81-9 acetylamino-(2-fluoro-4-methoxy-benzyl)-malonic acid diethyl ester 
• 354138-95-7 1,3-Dichloro-2-[(Z)-2-(2-fluoro-4-methoxy-phenyl)-vinyl]-5-methoxy-benzene 
• 354138-84-4 1,3-Dichloro-2-[(E)-2-(2-fluoro-4-methoxy-phenyl)-vinyl]-5-methoxy-benzene 
• 7656-31-7 o-fluoro-DL-tyrosine 
• 54788-29-3 2-fluoro-O-methyl-tyrosine 
• 349-18-8 N-acetyl-2-fluoro-O-methyl-tyrosine 
• 415920-29-5 (2R)-2-[[7-amino-2-[[(2-fluoro-4-methoxyphenyl)methyl]thio]-4-pteridinyl]amino]-1-propanol 
• 357613-01-5 2-Fluoro₄-methoxy-benzenemethanethiol 
• 421592-73-6 1,2-dihydro-4-[(2-fluoro-4-methoxyphenyl)-methyl]-5-methyl-3H-pyrazole-3-one 

Relevant academic research and scientific papers

Unusual Kinetic Profiles for Lewis Base-Catalyzed Sulfenocyclization of ortho -Geranylphenols in Hexafluoroisopropyl Alcohol

The kinetic behavior of the Lewis base-catalyzed sulfenocyclization of polyenes in hexafluoroisopropyl alcohol (HFIP) was explored. The rate of reaction is not dependent on the electronic properties of the terminal nucleophile, suggesting that this captur

Magnesiate-Utilized/Benzyne-Mediated Approach to Indenopyridones from 2-Pyridones: An Attempt to Synthesize the Indenopyridine Core of Haouamine

An efficient, short-staged synthesis of cis-fused indeno[2,1-b]- and indeno[1,2-c]pyridin-2-ones, starting from 2-pyridones, using magnesiates of type R3MgLi as nucleophilic and deprotonation agents, mediated by benzyne generated in situ, under optimized conditions, is described. Following the developed protocol, rare C4a-arylsubstituted indeno[2,1-b]pyridones, resembling the core of haouamine, were obtained. The protocol offering the one-pot synthesis directly from 2-pyridone is also described.

Isoindoline derivative and intermediate, preparation method, pharmaceutical composition and application thereof

The invention discloses an isoindoline derivative, and an intermediate, a preparation method, a pharmaceutical composition and application thereof. The isoindoline derivative of the invention and the pharmaceutical composition thereof can adjust productio

7-amino-2-alkylthiopteridin-4-yl-amines for the treatment of chemokine-related diseases

Pteridine compounds of formula (I) in which R1, R2, R3 and R4 are as specified in the claims, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in t

PYRIMIDINE-5-CARBOXAMIDE COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF

A compound of the formula wherein R1 is a heterocycle having a skeleton consisting of 3 to 15 atoms including 1 to 5 nitrogen atom(s), which heterocycle is attached by a secondary nitrogen atom constituting the heterocycle; X is an oxygen atom, a nitrogen atom optionally substituted by a hydrocarbon group having 1 to 5 carbon atom(s) or a sulfur atom optionally oxidized with 1 or 2 oxygen, Y is a bond or a C1-5 alkylene group, R2 is (1) a hydrogen atom, (2) a hydroxy group, (3) a C1-5 alkoxy group, (4) a C1-5 alkylthio group, (5) a carbocycle having 3 to 15 carbon atoms or (6) a heterocycle having a skeleton consisting of 3 to 15 atoms including 1 to 5 heteroatom(s), provided that when Y is a bond, R2 is a carbocycle having 3 to 15 carbon atoms or a heterocycle having a skeleton consisting of 3 to 15 atoms including 1 to 5 heteroatom(s) and; one of R3 and R4 is a hydrogen atom or a group of the formula: -Z-R5 (Z is a bond or C1-10 alkylene group optionally having substituent(s) and R5 is (1) a hydrogen atom, (2) a hydroxy group, (3) a C1-5 alkoxy group, (4) a nitrile group, (5) a C1-5 alkoxy-carbonyl group, (6) a carboxyl group, (7) a carbamoyl group, (8) a (mono or di-C1-5 alkyl)carbamoyl group, (9) an amino group, (10) a (di or mono-C1-5 alkyl)amino group, (11) a (C1-5 alkoxy-carbonyl)amino group, (12) a C1-5 alkylthio group, (13) a carbocycle having 3 to 15 carbon atoms or (14) a heterocycle having a skeleton consisting of 3 to 15 atoms including 1 to 5 heteroatom(s)); the other is a group of the formula: -Z-R5 (Z and R5 are as defined above); and R3 and R4 may form, together with the adjacent nitrogen atom, a heterocycle having a skeleton consisting of 3 to 15 atoms, which heterocycle is attached by a secondary nitrogen atom constituting the heterocycle, wherein the above-mentioned heterocycle and a carbocycle having 3 to 15 carbon atoms are each optionally substituted by substituent(s) selected from the group consisting of C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C7-16 aralkyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, C6-14 aryl, C1-8 alkoxy, C1-3 alkylenedioxy, hydroxy, halogen atom, amino, (di or mono-C1-5 alkyl)amino, (C1-5 alkoxy-carbonyl)amino, (C1-5 acyl)amino, (C1-5 acyl) (C1-5 alkyl)amino, C1-5 alkylthio, nitrile, nitro, C1-5 alkoxy-carbonyl, carboxyl, C1-5 alkyl-carbonyloxy, oxo, thioxo, C1-6 acyl group, sulfamoyl and (di or mono-C1-5 alkyl)sulfamoyl, or a salt thereof or a prodrug thereof have a superior cGMP specific phosphodiesterase (PDE) inhibitory activity, and can be used as an agent for the prophylaxis or treatment of cardiovascular diseases such as angina pectoris, heart failure, cardiac infarction, hypertension, arteriosclerosis and the like, allergic diseases such as asthma, or disorders of male or female genital function and the like.

Aqua(sulfato)platinum(II) Complexes with Variable Substituents in the 2-Phenyl Ring. 1. Synthesis and Antitumor and Estrogenic Properties

Erythro- and threo-configurated aqua(sulfato)platinum(II) complexes with variable substituents in the 2-phenyl ring (2-PtSO4 to 9-PtSO4: H, 4-F, 3-OH, 4-OH, 2,6-F2, 2,6-Cl2, 2-F/4-OH, 2-Cl/4-OH) were synthesized and tested for estrogenic and antitumor activities.The ligands were obtained by a three-step reaction.The stilbenes were reacted with a mixture of IN3 and NaN3 to yield the respective 1,2-diazido-1,2-diphenylethanes.The subsequent reduction with LiAlH4 led to the corresponding 1,2-diphenylethylenediamines.The (sulfato)platinum(II) complexes were synthesized by reaction of Ag2SO4 with the diiodo complexes, which had been obtained by coordination of the diamines with K2PtI4.Two complexes, erythro-8-PtSO4 and erythro-9-PtSO4, possess antitumor and estrogenic effects and are therefore of interest for the therapy of breast cancer.